PDHA1: Target/Biomarker Introduction, products summarized (antibody/ADC/bispecific/antigen/ORF vector/VLP) and disease/indication/condition/MOA for drug discovery and IVD
It's the GeneMedi's summary page for Target/Biomarker Introduction of PDHA1. The page also collects GeneMedi's different modalities and formats products for PDHA1 in therapeutics/drug discovery and IVD diagnostics, which is including antibody, ADC, bispecific, antigen, ORF vector, VLP, etc. With GeneMedi's target-insight database-GM ITD database, the PDHA1 target is also connected to human indications/diseases/conditions/MOA.
Target sublocation: Secreted Protein/Potential Cytokines.
The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 alpha 1 subunit containing the E1 active site, and plays a key role in the function of the PDH complex. Mutations in this gene are associated with pyruvate dehydrogenase E1-alpha deficiency and X-linked Leigh syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010]
Target ID | GM-SE1495 |
Target Name | PDHA1 |
Gene ID | 5160,18597,29554,100423990,119868382,101080765,407109,100051597 |
Gene Symbol and Synonyms | E1alpha,PDHA,Pdha-1,PDHA1,PDHAD,PDHCE1A,PHE1A |
Uniprot Accession | P08559,P26284,P49823,A7MB35 |
Uniprot Entry Name | ODPA_HUMAN,ODPA_RAT,ODPA_CANLF,ODPA_BOVIN |
Protein Sub-location | Secreted Protein/Potential Cytokines |
Category | |
Disease | N/A |
Gene Ensembl | ENSG00000131828 |
Target Classification | N/A |
Pre-made anti-PDHA1 inhibitory monoclonal antibody(mab, blocking antibody inhibitor)-benchmark antibody for drug discovery and mechanism of action (MOA) research
Pre-made anti-PDHA1 benchmark inhibitory monoclonal antibody(mab, blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). The anti-PDHA1 mab is expressed and produced by mammalian cell line as a benchmark reference therapeutic antibody for biological drug discovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Antibody Name | Species | Format | Classified by tag | Detail |
Anti-PDHA1 monoclonal antibody | Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine | mab | FACS/Biofunctional Antibody | Detail |
Recombinant multi-species ODPA/ PDHA1/ PDHA protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis
Genemedi produces Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine PDHA1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
Products Name | Species | Expression Platform | Detail |
PDHA1 protein | Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine | Mammalian cell | Detail |
Pre-made PDHA1 viral vector in GM Promise-ORFTM
Cat No. | Products name | NM ID | Species | Type | Detail |
pGMLP003325 | human PDHA1 Lentivirus plasmid | NM_000284 | Human | Lentivirus plasmid | Detail |
vGMLP003325 | human PDHA1 Lentivirus particle | NM_000284 | Human | Lentivirus particle | Detail |
pGMLV000711 | house mouse Pdha1 Lentivirus plasmid | NM_008810.3 | House Mouse | Lentivirus plasmid | Detail |
pGMAD000022 | rat Pdha1 Adenovirus plasmid | NM_001004072.2 | Rat | Adenovirus plasmid | Detail |
pGMLPm002182 | mouse Pdha1 Lentivirus plasmid | NM_008810 | Mouse | Lentivirus plasmid | Detail |
vGMLV000711 | house mouse Pdha1 Lentivirus particle | NM_008810.3 | House Mouse | Lentivirus particle | Detail |
vGMAD000022 | rat Pdha1 Adenovirus particle | NM_001004072.2 | Rat | Adenovirus particle | Detail |
vGMLPm002182 | mouse Pdha1 Lentivirus particle | NM_008810 | Mouse | Lentivirus particle | Detail |
About Promise-ORFTM:
Discover the largest collection of ORF/cDNA expression clones from different species, including human, mouse, rat, and more with GeneMedi's Promise-ORFTM. Our collection of ORFs expression clones come in verified mammalian or viral vectors lentivirus, AAV, and adenovirus) and our Promise-ORFTM viral-ready expression vectors make it easy for you to improve viral vector packaging efficiency or directly transfect mammalian cells, resulting in stronger and easier expression detection. Click to search your GOI
If you want to obtain higher quantities of plasmids (mg), please visit GM TransExcellent Plasmid DNA Rapid Preparation Service.