- • Up to 20% off your first purchase
- • Bulk quantities available
- • Citation Reward application
Sample Application
- Animal health test
- In-vitro diagnostics
- Food & Feed Safety
- Environmental Safety
- New drug discovery
Supports
- Talk to our Expert:
[email protected] -
Talk to our sales:
[email protected]
Protocol Library Download
 |
 |
Anti-ODPA/ PDHA1/ PDHA functional antibody
Anti-ODPA/ PDHA1/ PDHA functional antibody for cell culture, ELISA & in-vivo assay
Go to PDHA1/PDHA1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE1495-Ab-1/ GM-Tg-hg-SE1495-Ab-2 | Anti-Human PDHA1 monoclonal antibody | Human |
| GM-Tg-rg-SE1495-Ab-1/ GM-Tg-rg-SE1495-Ab-2 | Anti-Rat PDHA1 monoclonal antibody | Rat |
| GM-Tg-mg-SE1495-Ab-1/ GM-Tg-mg-SE1495-Ab-2 | Anti-Mouse PDHA1 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE1495-Ab-1/ GM-Tg-cynog-SE1495-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PDHA1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE1495-Ab-1/ GM-Tg-felg-SE1495-Ab-2 | Anti-Feline PDHA1 monoclonal antibody | Feline |
| GM-Tg-cang-SE1495-Ab-1/ GM-Tg-cang-SE1495-Ab-2 | Anti-Canine PDHA1 monoclonal antibody | Canine |
| GM-Tg-bovg-SE1495-Ab-1/ GM-Tg-bovg-SE1495-Ab-2 | Anti-Bovine PDHA1 monoclonal antibody | Bovine |
| GM-Tg-equg-SE1495-Ab-1/ GM-Tg-equg-SE1495-Ab-2 | Anti-Equine PDHA1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE1495-Ab-1/ GM-Tg-hg-SE1495-Ab-2; GM-Tg-rg-SE1495-Ab-1/ GM-Tg-rg-SE1495-Ab-2; GM-Tg-mg-SE1495-Ab-1/ GM-Tg-mg-SE1495-Ab-2; GM-Tg-cynog-SE1495-Ab-1/ GM-Tg-cynog-SE1495-Ab-2; GM-Tg-felg-SE1495-Ab-1/ GM-Tg-felg-SE1495-Ab-2; GM-Tg-cang-SE1495-Ab-1/ GM-Tg-cang-SE1495-Ab-2; GM-Tg-bovg-SE1495-Ab-1/ GM-Tg-bovg-SE1495-Ab-2; GM-Tg-equg-SE1495-Ab-1/ GM-Tg-equg-SE1495-Ab-2 |
| Products Name | Anti-PDHA1 monoclonal antibody |
| Format | mab |
| Target Name | PDHA1 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-PDHA1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE1495-Ag-1 | Recombinant multi-species ODPA/ PDHA1/ PDHA protein |
| ORF Viral Vector | pGMLP003325 | human PDHA1 Lentivirus plasmid |
| ORF Viral Vector | vGMLP003325 | human PDHA1 Lentivirus particle |
| ORF Viral Vector | pGMLV000711 | house mouse Pdha1 Lentivirus plasmid |
| ORF Viral Vector | pGMAD000022 | rat Pdha1 Adenovirus plasmid |
| ORF Viral Vector | pGMLPm002182 | mouse Pdha1 Lentivirus plasmid |
| ORF Viral Vector | vGMLV000711 | house mouse Pdha1 Lentivirus particle |
| ORF Viral Vector | vGMAD000022 | rat Pdha1 Adenovirus particle |
| ORF Viral Vector | vGMLPm002182 | mouse Pdha1 Lentivirus particle |
Target information
| Target ID | GM-SE1495 |
| Target Name | PDHA1 |
| Gene ID | 5160,18597,29554,100423990,119868382,101080765,407109,100051597 |
| Gene Symbol and Synonyms | E1alpha,PDHA,Pdha-1,PDHA1,PDHAD,PDHCE1A,PHE1A |
| Uniprot Accession | P08559,P26284,P49823,A7MB35 |
| Uniprot Entry Name | ODPA_HUMAN,ODPA_RAT,ODPA_CANLF,ODPA_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000131828 |
| Target Classification | N/A |
The target: PDHA1, gene name: PDHA1, also named as PDHA, PDHAD, PDHCE1A, PHE1A. The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 alpha 1 subunit containing the E1 active site, and plays a key role in the function of the PDH complex. Mutations in this gene are associated with pyruvate dehydrogenase E1-alpha deficiency and X-linked Leigh syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
Facebook
LinkedIn
Twitter
