Products
Caplacizumab Biosimilar Nanobody (VWF) for Research
Pre-Made Caplacizumab biosimilar, Nanobody, Anti-VWF Antibody: Anti-F8VWF/VWD therapeutic antibody is a biosimilar expressed by mammalian cell line as a benchmark reference therapeutic antibody for biological drug disovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Caplacizumab (INN; trade name Cablivi) is a bivalent single-domain antibody (VHH) designed for the treatment of thrombotic thrombocytopenic purpura and thrombosis.
Order Information
| Catalog No. | Package | Price(In USD) |
|---|---|---|
| GMP-Bios-ab-093-1mg | 1mg | 3090 |
| GMP-Bios-ab-093-10mg | 10mg | |
| GMP-Bios-ab-093-100mg | 100mg | |
| GMP-Bios-ab-093-xmg | ≥100mg |
Product Details
| Products Name (INN Index) | Pre-Made Caplacizumab biosimilar, Nanobody, Anti-VWF Antibody: Anti-F8VWF/VWD therapeutic antibody |
| INN Name | Caplacizumab |
| Target | VWF |
| Format | Nanobody |
| Derivation | Humanized |
| Species Reactivity | Human |
| CH1 Isotype | na |
| VD LC | na |
| Highest_Clin_Trial (Jan '20) | Approved |
| Est. Status | NFD |
| 100% SI Structure | None |
| 99% SI Structure | None |
| 95-98% SI Structure | None |
| Year Proposed | 2011 |
| Year Recommended | 2012 |
| Companies | Ablynx |
| Conditions Approved | Thrombotic thrombocytopenic purpura |
| Conditions Active | na |
| Conditions Discontinued | Thrombosis |
| Development Tech | Nanobody Technology |
About target - VWF
1. Protein von Willebrand factor
2. Gene VWF
3. Organism Homo sapiens (Human)
Function
Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma.
