Products
Elgemtumab Biosimilar Monoclonal Antibody (HER3) for Research
Pre-Made Elgemtumab biosimilar, Whole mAb, Anti-ERBB3/Erbb-3 Antibody: Anti-ErbB-3/FERLK/HER3/LCCS2/MDA-BF-1/VSCN1/c-erbB-3/c-erbB3/erbB3-S/p180-ErbB3/p45-sErbB3/p85-sErbB3 therapeutic antibody is a biosimilar expressed by mammalian cell line as a benchmark reference therapeutic antibody for biological drug disovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Elgemtumab, also known as LJM716, is a high- affinity IgG1κ type monoclonal antibodies selected from a Human Combinatorial Antibody Library (HuCAL). It can specifically bind to ERBB3 to neutralize multiple modes of ERBB3 activation.
Order Information
| Catalog No. | Package | List Price(In USD) | Discount off | Discount Price |
|---|---|---|---|---|
| GMP-Bios-ab-170-1mg | 1mg | 3090 |
Size： 1mg | 10mg | 100mg
Product Details
| Products Name (INN Index) | Pre-Made Elgemtumab biosimilar, Whole mAb, Anti-ERBB3/Erbb-3 Antibody: Anti-ErbB-3/FERLK/HER3/LCCS2/MDA-BF-1/VSCN1/c-erbB-3/c-erbB3/erbB3-S/p180-ErbB3/p45-sErbB3/p85-sErbB3 therapeutic antibody |
| INN Name | Elgemtumab |
| Target | Erbb-3 |
| Format | Whole mAb |
| Derivation | Human |
| Species Reactivity | Human |
| CH1 Isotype | IgG1 |
| VD LC | Kappa |
| Highest_Clin_Trial (Jan '20) | Phase-I/II |
| Est. Status | Discontinued |
| 100% SI Structure | None |
| 99% SI Structure | None |
| 95-98% SI Structure | 4p59:HL |
| Year Proposed | 2014 |
| Year Recommended | 2015 |
| Companies | MorphoSys;Novartis;Memorial Sloan-Kettering Cancer Center;Novartis Oncology |
| Conditions Approved | na |
| Conditions Active | na |
| Conditions Discontinued | Breast cancer;Gastric cancer;Head and neck cancer;Oesophageal cancer;Solid tumours |
| Development Tech | Medarex HuMAb Mouse |
About target - ERBB3
1. Protein Receptor tyrosine-protein kinase erbB-3
2. Gene ERBB3
3. Organism Homo sapiens (Human)
Function
Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778).
May also be activated by CSPG5 (PubMed:15358134).
Involved in the regulation of myeloid cell differentiation (PubMed:27416908).
Catalytic activity
ATP + L-tyrosyl-[protein] = ADP + H+ + O-phospho-L-tyrosyl-[protein]
EC:2.7.10.1
Source: Rhea.
