Products
Murlentamab Biosimilar Monoclonal Antibody (AMHR2) for Research
Pre-Made Murlentamab biosimilar, Whole mAb, Anti-AMHR2 Antibody: Anti-AMHR/MISR2/MISRII/MRII therapeutic antibody is a biosimilar expressed by mammalian cell line as a benchmark reference therapeutic antibody for biological drug disovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Order Information
| Catalog No. | Package | List Price(In USD) | Discount off | Discount Price |
|---|---|---|---|---|
| GMP-Bios-ab-359-1mg | 1mg | 3090 |
Size： 1mg | 10mg | 100mg
Product Details
| Products Name (INN Index) | Pre-Made Murlentamab biosimilar, Whole mAb, Anti-AMHR2 Antibody: Anti-AMHR/MISR2/MISRII/MRII therapeutic antibody |
| INN Name | Murlentamab |
| Target | AMHR2 |
| Format | Whole mAb |
| Derivation | Humanized |
| Species Reactivity | Human |
| CH1 Isotype | IgG1 |
| VD LC | Kappa |
| Highest_Clin_Trial (Jan '20) | Phase-II |
| Est. Status | Active |
| 100% SI Structure | None |
| 99% SI Structure | None |
| 95-98% SI Structure | None |
| Year Proposed | 2018 |
| Year Recommended | 2019 |
| Companies | LFB Biotechnologies;GamaMabs Pharma |
| Conditions Approved | na |
| Conditions Active | Colorectal cancer;Gynaecological cancer |
| Conditions Discontinued | na |
| Development Tech | na |
About target - AMHR2
1. Protein Anti-Muellerian hormone type-2 receptor
2. Gene AMHR2
3. Organism Homo sapiens (Human)
Function
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone.
Catalytic activity
ATP + L-threonyl-[receptor-protein] = ADP + H+ + O-phospho-L-threonyl-[receptor-protein]
EC:2.7.11.30
Source: Rhea.
