Products
Nidanilimab Biosimilar Monoclonal Antibody (IL-1RAP) for Research
Pre-Made Nidanilimab biosimilar, Whole mAb, Anti-IL1RAP Antibody: Anti-C3orf13/IL-1RAcP/IL1R3 therapeutic antibody is a biosimilar expressed by mammalian cell line as a benchmark reference therapeutic antibody for biological drug disovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Order Information
| Catalog No. | Package | List Price(In USD) | Discount off | Discount Price |
|---|---|---|---|---|
| GMP-Bios-ab-375-1mg | 1mg | 3090 |
Size： 1mg | 10mg | 100mg
Product Details
| Products Name (INN Index) | Pre-Made Nidanilimab biosimilar, Whole mAb, Anti-IL1RAP Antibody: Anti-C3orf13/IL-1RAcP/IL1R3 therapeutic antibody |
| INN Name | Nidanilimab |
| Target | IL1RAP |
| Format | Whole mAb |
| Derivation | Humanized |
| Species Reactivity | Human |
| CH1 Isotype | IgG1 |
| VD LC | Kappa |
| Highest_Clin_Trial (Jan '20) | Phase-II |
| Est. Status | Active |
| 100% SI Structure | None |
| 99% SI Structure | None |
| 95-98% SI Structure | None |
| Year Proposed | 2018 |
| Year Recommended | 2019 |
| Companies | Lund University;Cantargia |
| Conditions Approved | na |
| Conditions Active | Non-small cell lung cancer;Pancreatic cancer;Solid tumours |
| Conditions Discontinued | na |
| Development Tech | na |
About target - IL1RAP
1. Protein Interleukin-1 receptor accessory protein
2. Gene IL1RAP
3. Organism Homo sapiens (Human)
Function
Coreceptor for IL1RL2 in the IL-36 signaling system (By similarity).
Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Coreceptor for IL1RL1 in the IL-33 signaling system. Can bidirectionally induce pre- and postsynaptic differentiation of neurons by trans-synaptically binding to PTPRD (By similarity).
May play a role in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (Probable).
Isoform 2:
Associates with secreted ligand-bound IL1R2 and increases the affinity of secreted IL1R2 for IL1B; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors (PubMed:12530978).
Enhances the ability of secreted IL1R1 to inhibit IL-33 signaling (By similarity).
Isoform 4:
Unable to mediate canonical IL-1 signaling (PubMed:19481478).
Required for Src phosphorylation by IL1B. May be involved in IL1B-potentiated NMDA-induced calcium influx in neurons (By similarity).
Catalytic activity
H2O + NAD+ = ADP-D-ribose + H+ + nicotinamide
EC:3.2.2.6
This reaction proceeds in the forward
Source: Rhea.
