Products
Zelminemab Biosimilar Monoclonal Antibody (PAC1 Receptor) for Research
Pre-Made Zelminemab biosimilar, Whole mAb, Anti-ADCYAP1R1/PAC1R Antibody: Anti-PAC1/PACAPR/PACAPRI therapeutic antibody is a biosimilar expressed by mammalian cell line as a benchmark reference therapeutic antibody for biological drug disovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Order Information
| Catalog No. | Package | List Price(In USD) | Discount off | Discount Price |
|---|---|---|---|---|
| GMP-Bios-ab-643-1mg | 1mg | 3090 |
Size： 1mg | 10mg | 100mg
Product Details
| Products Name (INN Index) | Pre-Made Zelminemab biosimilar, Whole mAb, Anti-ADCYAP1R1/PAC1R Antibody: Anti-PAC1/PACAPR/PACAPRI therapeutic antibody |
| INN Name | Zelminemab |
| Target | PAC1R |
| Format | Whole mAb |
| Derivation | |
| Species Reactivity | Human |
| CH1 Isotype | IgG1 |
| VD LC | Kappa |
| Highest_Clin_Trial (Jan '20) | Phase-II |
| Est. Status | Active |
| 100% SI Structure | None |
| 99% SI Structure | None |
| 95-98% SI Structure | None |
| Year Proposed | 2019 |
| Year Recommended | 2020 |
| Companies | Amgen |
| Conditions Approved | na |
| Conditions Active | Migraine |
| Conditions Discontinued | na |
| Development Tech | na |
About target - ADCYAP1R1
1. Protein Protein-glutamine gamma-glutamyltransferase 2
2. Gene ADCYAP1R1
3. Organism Homo sapiens (Human)
Function
This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract.
