PMAIP1 Gene (Phorbol-12-Myristate-13-Acetate-Induced Protein 1)
Summary of PMAIP1 Gene
|Official Symbol||PMAIP1 provided by HGNC|
|Official Full Name||phorbol-12-myristate-13-acetate-induced protein 1 provided by HGNC|
|See related||Ensembl:ENSG00000141682 MIM:604959|
|Gene type||protein coding|
|Lineage||Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo|
|Also known as||APR; NOXA|
|Expression||Biased expression in bone marrow (RPKM 33.1), placenta (RPKM 8.9) and 12 other tissues See more|
PMAIP1 Gene - Genemedi's Promise-ORFTM
|Product Name||Contents||Price(In USD)||Qty (Quantity)||Sum(In USD)|
|Mouse Pmaip1 Lenti-Virus plasmid (NM_021451)||
Product Type: Lentivirus plasmid (overexpression)
Fluorescent Label: GFP+PURO
Fusion Tag: 3xflag
|Optional Choice||Plasmid Validation(qPCR)||500|
|Optional Choice||Plasmid Validation(Western Blot)||500|
Function of PMAIP1 Gene
Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1.
Expression of PMAIP1 Gene
Highly expressed in adult T-cell leukemia cell line.
Up-regulated by p53/TP53, phorbol esters, double-stranded RNA, IFNB1/IFN-beta and viruses.
Sample Image:Subunit structure
Interacts with MCL1, BCL2A1 and BAX.
Q13794 has binary interactions with 3 proteins