PMAIP1 Gene (Phorbol-12-Myristate-13-Acetate-Induced Protein 1)
Summary of PMAIP1 Gene
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PMAIP1 provided by HGNC |
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phorbol-12-myristate-13-acetate-induced protein 1 provided by HGNC |
| HGNC:HGNC:9108 |
| Ensembl:ENSG00000141682 MIM:604959 |
| protein coding |
| VALIDATED |
| Homo sapiens |
| Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo |
| APR; NOXA |
| Biased expression in bone marrow (RPKM 33.1), placenta (RPKM 8.9) and 12 other tissues See more |
| mouse |
Product Name | Contents | Price(In USD) | Qty (Quantity) | Sum(In USD) |
---|---|---|---|---|
Mouse Pmaip1 Lenti-Virus plasmid (NM_021451) |
Species: mouse Product Type: Lentivirus plasmid (overexpression) Fluorescent Label: GFP+PURO Fusion Tag: 3xflag Promoter: CMV Resistance: Amplicin size: 5ug |
518 | ||
Optional Choice | Plasmid Validation(qPCR) | 500 | ||
Optional Choice | Plasmid Validation(Western Blot) | 500 | ||
Shipping Cost: | 169.00 | |||
Total: | ||||
Function of PMAIP1 Gene
Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1.
Expression of PMAIP1 Gene
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