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Summary of PMAIP1 Gene

Official Symbol PMAIP1 provided by HGNC
Official Full Name phorbol-12-myristate-13-acetate-induced protein 1 provided by HGNC
Primary source HGNC:HGNC:9108
See related Ensembl:ENSG00000141682  MIM:604959
Gene type protein coding
RefSeq status VALIDATED
Organism Homo sapiens
Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as APR; NOXA
Expression Biased expression in bone marrow (RPKM 33.1), placenta (RPKM 8.9) and 12 other tissues See more
Orthologs mouse


PMAIP1 Gene - Genemedi's Promise-ORFTM

Product Name Contents Price(In USD) Qty (Quantity) Sum(In USD)
Mouse Pmaip1 Lenti-Virus plasmid (NM_021451) Species: mouse
Product Type: Lentivirus plasmid (overexpression)
Fluorescent Label: GFP+PURO
Fusion Tag: 3xflag
Promoter: CMV
Resistance: Amplicin
size: 5ug
518
Optional Choice Plasmid Validation(qPCR) 500
Optional Choice Plasmid Validation(Western Blot) 500
Shipping Cost: 169.00
Total:
Search ORF/cDNA expression clones of other genes



Function of PMAIP1 Gene


Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1.


Expression of PMAIP1 Gene


Tissue specificity

Highly expressed in adult T-cell leukemia cell line.

Induction

Up-regulated by p53/TP53, phorbol esters, double-stranded RNA, IFNB1/IFN-beta and viruses.

Sample Image:

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Interaction of PMAIP1 Gene


Subunit structure

Interacts with MCL1, BCL2A1 and BAX.

Binary interactions

Q13794 has binary interactions with 3 proteins

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