Human GPX1/GPXD/ GSHPX1 ORF/cDNA clone-Adenovirus plasmid (NM_000581.3)

Pre-made Human GPX1/GPXD/ GSHPX1 adenoviral expression plasmid for GPX1 adenovirus packaging, GPX1 adenovirus.

Our GM-Adenovirus vector is optimized with the GMVC-modified Adeasy adenovirus packaging system. Find more about the GMVC-modified adenovirus packaging system.

Target products collectionGo to GPX1/GPXD products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)



Product information

Catalog No. Product Name Plasmid Grade Plasmid quantity
pGMAD000015 Human GPX1 Adenovirus plasmid Research Grade 10mg, 50mg, 100mg, 500mg, >1g
GMP-like Grade 10mg, 50mg, 100mg, 500mg, >1g
High Quality (HQ) Grade
Seed 5ug


Product Description

Catalog ID pGMAD000015
Gene Name GPX1
Accession Number NM_000581.3
Gene ID 2876
Species Human
Product Type Adenovirus plasmid (overexpression)
Insert Length 612 bp
Gene Alias GPXD, GSHPX1
Fluorescent Reporter EGFP
Mammalian Cell Selection
Fusion Tag Null
Promoter CMV
Resistance Amplicin

Reference




    Data / case study


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    Associated products


    Category Cat No. Products Name
    Target Antibody GM-Tg-g-T70654-Ab Anti-GPX1 monoclonal antibody
    Target Antigen GM-Tg-g-T70654-Ag GPX1 protein
    ORF Viral Vector pGMAD000015 Human GPX1 Adenovirus plasmid
    ORF Viral Vector pGMAD000415 Human GPX1 Adenovirus plasmid
    ORF Viral Vector vGMAD000015 Human GPX1 Adenovirus particle
    ORF Viral Vector vGMAD000415 Human GPX1 Adenovirus particle


    Target information

    Target ID GM-T70654
    Target Name GPX1
    Gene ID 2876, 14775, 706732, 24404, 101083751, 442961, 281209, 100053396
    Gene Symbol and Synonyms CGPx,Gpx,GPx-1,GPX1,GPXD,GSHPx,GSHPx-1,GSHPX1
    Uniprot Accession P07203
    Uniprot Entry Name GPX1_HUMAN
    Protein Sub-location Introcelluar Protein
    Category Therapeutics Target
    Disease Lung Cancer
    Gene Ensembl ENSG00000233276
    Target Classification Not Available

    The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Other studies indicate that H2O2 is also essential for growth-factor mediated signal transduction, mitochondrial function, and maintenance of thiol redox-balance; therefore, by limiting H2O2 accumulation, glutathione peroxidases are also involved in modulating these processes. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is the most abundant, is ubiquitously expressed and localized in the cytoplasm, and whose preferred substrate is hydrogen peroxide. It is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. This gene contains an in-frame GCG trinucleotide repeat in the coding region, and three alleles with 4, 5 or 6 repeats have been found in the human population. The allele with 4 GCG repeats has been significantly associated with breast cancer risk in premenopausal women. Alternatively spliced transcript variants have been found for this gene. Pseudogenes of this locus have been identified on chromosomes X and 21. [provided by RefSeq, Aug 2017]



    About GMVC

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    GMVC (GM Vector Core) is GeneMedi’s unique platform for QbD Viral vectors Processes development and manufacturing. In GMVC, our core expertise lies in the tailored production of viral vectors, including adeno-associated virus (AAV), lentivirus, and adenovirus. Our state-of-the-art facilities are equipped for scalable manufacturing, ensuring high-quality viral vector production to meet both research and therapeutic needs. Our expert team specializes in process development, leveraging innovative technology and extensive industry knowledge to provide clients with tailored solutions that exceed expectations. GMVC will be the ideal partner for scientists and healthcare professionals seeking reliable and efficient viral vector production services.