Anti-GPX1 monoclonal antibody
Pre-made anti-GPX1 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
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(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
Product information
Catalog No. | Product Name | Species Reactivity |
---|---|---|
GM-Tg-hg-T70654-Ab-1/ GM-Tg-hg-T70654-Ab-2 | Anti-Human GPX1 monoclonal antibody | Human |
GM-Tg-rg-T70654-Ab-1/ GM-Tg-rg-T70654-Ab-2 | Anti-Rat GPX1 monoclonal antibody | Rat |
GM-Tg-mg-T70654-Ab-1/ GM-Tg-mg-T70654-Ab-2 | Anti-Mouse GPX1 monoclonal antibody | Mouse |
GM-Tg-cynog-T70654-Ab-1/ GM-Tg-cynog-T70654-Ab-2 | Anti-Cynomolgus/ Rhesus macaque GPX1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
GM-Tg-felg-T70654-Ab-1/ GM-Tg-felg-T70654-Ab-2 | Anti-Feline GPX1 monoclonal antibody | Feline |
GM-Tg-cang-T70654-Ab-1/ GM-Tg-cang-T70654-Ab-2 | Anti-Canine GPX1 monoclonal antibody | Canine |
GM-Tg-bovg-T70654-Ab-1/ GM-Tg-bovg-T70654-Ab-2 | Anti-Bovine GPX1 monoclonal antibody | Bovine |
GM-Tg-equg-T70654-Ab-1/ GM-Tg-equg-T70654-Ab-2 | Anti-Equine GPX1 monoclonal antibody | Equine |
Size: 1mg | 10mg | 100mg
Product Description
Catalog No. | GM-Tg-hg-T70654-Ab-1/ GM-Tg-hg-T70654-Ab-2; GM-Tg-rg-T70654-Ab-1/ GM-Tg-rg-T70654-Ab-2; GM-Tg-mg-T70654-Ab-1/ GM-Tg-mg-T70654-Ab-2; GM-Tg-cynog-T70654-Ab-1/ GM-Tg-cynog-T70654-Ab-2; GM-Tg-felg-T70654-Ab-1/ GM-Tg-felg-T70654-Ab-2; GM-Tg-cang-T70654-Ab-1/ GM-Tg-cang-T70654-Ab-2; GM-Tg-bovg-T70654-Ab-1/ GM-Tg-bovg-T70654-Ab-2; GM-Tg-equg-T70654-Ab-1/ GM-Tg-equg-T70654-Ab-2 |
Products Name | Anti-GPX1 monoclonal antibody |
Format | mab |
Target Name | GPX1 |
Protein Sub-location | Introcelluar Protein |
Category of antibody | Therapeutics Target antibody |
Derivation (species) | Mouse |
CH1+2+3 Isotype (Receptor identification) | IgG |
Type of Light Chain (VD-LC) | N/A |
Expression platform | Mammalian Expression |
Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
Tag | Fc |
Products description | Pre-made anti-GPX1 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation | Lyophilized from sterile PBS, PH 7.4 |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Category | Cat No. | Products Name |
Target Antigen | GM-Tg-g-T70654-Ag-1 | Recombinant multi-species GPX1/ GPXD/ GSHPX1 protein |
ORF Viral Vector | vGMAD000015 | human GPX1 Adenovirus particle |
ORF Viral Vector | pGMAD000015 | human GPX1 Adenovirus plasmid |
ORF Viral Vector | pGMAD000415 | human GPX1 Adenovirus plasmid |
ORF Viral Vector | vGMAD000415 | human GPX1 Adenovirus particle |
ORF Viral Vector | pGMLPm002579 | mouse Gpx1 Lentivirus plasmid |
ORF Viral Vector | vGMLPm002579 | mouse Gpx1 Lentivirus particle |
Target information
Target ID | GM-T70654 |
Target Name | GPX1 |
Gene ID | 2876,14775,24404,706732,442961,101083751,281209,100053396 |
Gene Symbol and Synonyms | CGPx,Gpx,GPx-1,GPX1,GPXD,GSHPx,GSHPx-1,GSHPX1 |
Uniprot Accession | P07203,P04041,P00435 |
Uniprot Entry Name | GPX1_HUMAN,GPX1_RAT,GPX1_BOVIN |
Protein Sub-location | Introcelluar Protein |
Category | Therapeutics Target |
Disease | Lung Cancer |
Gene Ensembl | ENSG00000233276 |
Target Classification | N/A |
The target: GPX1, gene name: GPX1, also named as GPXD, GSHPX1. The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Other studies indicate that H2O2 is also essential for growth-factor mediated signal transduction, mitochondrial function, and maintenance of thiol redox-balance; therefore, by limiting H2O2 accumulation, glutathione peroxidases are also involved in modulating these processes. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is the most abundant, is ubiquitously expressed and localized in the cytoplasm, and whose preferred substrate is hydrogen peroxide. It is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. This gene contains an in-frame GCG trinucleotide repeat in the coding region, and three alleles with 4, 5 or 6 repeats have been found in the human population. The allele with 4 GCG repeats has been significantly associated with breast cancer risk in premenopausal women. Alternatively spliced transcript variants have been found for this gene. Pseudogenes of this locus have been identified on chromosomes X and 21. [provided by RefSeq, Aug 2017].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.