Human PSENEN/ACNINV2/MDS033 ORF/cDNA clone-Lentivirus plasmid (NM_172341)

Cat. No.: pGMLP002691
Size: 10 µg
Concentration: generally 0.5ug/ul, usually not less than 0.3ug/ul
Leading Time: 3-7 working days

Pre-made Human PSENEN/ACNINV2/MDS033 Lentiviral expression plasmid for PSENEN lentivirus packaging, PSENEN lentivirus production, overexpression stable cell line development, cell transient transfection and gene delivery targeting T/B/NK cells, macrophages, cardiomyocytes, hepatocytes, and neurons.

Our GM-Lentiviral vector is seamlessly integrated with the GM lentivirus packaging system. Discover more about the GM lentivirus packaging system.

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Product Description

Catalog ID pGMLP002691
Gene Name PSENEN
Accession Number NM_172341
Gene ID 55851
Species Human
Product Type Lentivirus plasmid (overexpression)
Insert Length 306 bp
Gene Alias ACNINV2,MDS033,MSTP064,PEN-2,PEN2
Fluorescent Reporter ZsGreen
Mammalian Cell Selection Puromyocin
Fusion Tag 3xflag (C-Terminal)
Promoter CMV
Resistance Amplicin
ORF Nucleotide Sequence ATGAACCTGGAGCGAGTGTCCAATGAGGAGAAATTGAACCTGTGCCGGAAGTACTACCTGGGGGGGTTTGCTTTCCTGCCTTTTCTCTGGTTGGTCAACATCTTCTGGTTCTTCCGAGAGGCCTTCCTTGTCCCAGCCTACACAGAACAGAGCCAAATCAAAGGCTATGTCTGGCGCTCAGCTGTGGGCTTCCTCTTCTGGGTGATAGTGCTCACCTCCTGGATCACCATCTTCCAGATCTACCGGCCCCGCTGGGGTGCCCTTGGGGACTACCTCTCCTTCACCATACCCCTGGGCACCCCCTGA
ORF Protein Sequence MNLERVSNEEKLNLCRKYYLGGFAFLPFLWLVNIFWFFREAFLVPAYTEQSQIKGYVWRSAVGFLFWVIVLTSWITIFQIYRPRWGALGDYLSFTIPLGTP

Reference




    Data / case study


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    Associated products


    Category Cat No. Products Name
    Target Antibody GM-Tg-g-TA067-Ab Anti-PEN2/ PSENEN/ ACNINV2 monoclonal antibody
    Target Antigen GM-Tg-g-TA067-Ag PSENEN VLP (virus-like particle)
    ORF Viral Vector pGMLP002691 Human PSENEN Lentivirus plasmid
    ORF Viral Vector vGMLP002691 Human PSENEN Lentivirus particle


    Target information

    Target ID GM-TA067
    Target Name PSENEN
    Gene ID 55851, 66340, 100429005, 292788, 101084076, 476479, 493993, 100051536
    Gene Symbol and Synonyms 1700023M09Rik,ACNINV2,MDS033,MSTP064,PEN-2,PEN2,PSENEN,RGD1312037
    Uniprot Accession Q9NZ42
    Uniprot Entry Name PEN2_HUMAN
    Protein Sub-location Transmembrane Protein
    Category Therapeutics Target
    Disease Not Available
    Gene Ensembl ENSG00000205155
    Target Classification Not Available

    Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase. Mutations resulting in haploinsufficiency for this gene cause familial acne inversa-2 (ACNINV2). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]



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