Human CST3/ARMD11/HEL-S-2 ORF/cDNA clone-Lentivirus plasmid (NM_000099)

Cat. No.: pGMLP002896
Size: 10 µg
Concentration: generally 0.5ug/ul, usually not less than 0.3ug/ul
Leading Time: 3-7 working days

Pre-made Human CST3/ARMD11/HEL-S-2 Lentiviral expression plasmid for CST3 lentivirus packaging, CST3 lentivirus production, overexpression stable cell line development, cell transient transfection and gene delivery targeting T/B/NK cells, macrophages, cardiomyocytes, hepatocytes, and neurons.

Our GM-Lentiviral vector is seamlessly integrated with the GM lentivirus packaging system. Discover more about the GM lentivirus packaging system.

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Product Description

Catalog ID pGMLP002896
Gene Name CST3
Accession Number NM_000099
Gene ID 1471
Species Human
Product Type Lentivirus plasmid (overexpression)
Insert Length 441 bp
Gene Alias ARMD11,HEL-S-2
Fluorescent Reporter ZsGreen
Mammalian Cell Selection Puromyocin
Fusion Tag 3xflag (C-Terminal)
Promoter CMV
Resistance Amplicin
ORF Nucleotide Sequence ATGGCCGGGCCCCTGCGCGCCCCGCTGCTCCTGCTGGCCATCCTGGCCGTGGCCCTGGCCGTGAGCCCCGCGGCCGGCTCCAGTCCCGGCAAGCCGCCGCGCCTAGTGGGAGGCCCCATGGACGCCAGCGTGGAGGAGGAGGGTGTGCGGCGTGCACTGGACTTTGCCGTCGGCGAGTACAACAAAGCCAGCAACGACATGTACCACAGCCGCGCGCTGCAGGTGGTGCGCGCCCGCAAGCAGATCGTAGCTGGGGTGAACTACTTCTTGGACGTGGAGCTGGGCCGAACCACGTGTACCAAGACCCAGCCCAACTTGGACAACTGCCCCTTCCATGACCAGCCACATCTGAAAAGGAAAGCATTCTGCTCTTTCCAGATCTACGCTGTGCCTTGGCAGGGCACAATGACCTTGTCGAAATCCACCTGTCAGGACGCCTAG
ORF Protein Sequence MAGPLRAPLLLLAILAVALAVSPAAGSSPGKPPRLVGGPMDASVEEEGVRRALDFAVGEYNKASNDMYHSRALQVVRARKQIVAGVNYFLDVELGRTTCTKTQPNLDNCPFHDQPHLKRKAFCSFQIYAVPWQGTMTLSKSTCQDA

Reference




    Data / case study


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    Associated products


    Category Cat No. Products Name
    Target Antibody GM-Tg-g-MP0338-Ab Anti-CYTC/ CST3/ ARMD11 monoclonal antibody
    Target Antigen GM-Tg-g-MP0338-Ag CST3 VLP (virus-like particle)
    ORF Viral Vector pGMLP002896 Human CST3 Lentivirus plasmid
    ORF Viral Vector vGMLP002896 Human CST3 Lentivirus particle


    Target information

    Target ID GM-MP0338
    Target Name CST3
    Gene ID 1471, 13010, 574313, 100058494
    Gene Symbol and Synonyms ARMD11,CST3,CysC,HEL-S-2
    Uniprot Accession P01034
    Uniprot Entry Name CYTC_HUMAN
    Protein Sub-location Transmembrane Protein
    Category Diagnostics Biomarker
    Disease carcinoma, Diabetic Nephropathy, Nephrotoxicity, Sjogren's syndrome salivary, Perinatal necrotizing enterocolitis, Acute kidney failure, Asphyxia neonatorum, Dent disease, Metabolic syndrome, Nephropathy induced by heavy metals, Renal fibrosis
    Gene Ensembl ENSG00000101439
    Target Classification Not Available

    The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes the most abundant extracellular inhibitor of cysteine proteases, which is found in high concentrations in biological fluids and is expressed in virtually all organs of the body. A mutation in this gene has been associated with amyloid angiopathy. Expression of this protein in vascular wall smooth muscle cells is severely reduced in both atherosclerotic and aneurysmal aortic lesions, establishing its role in vascular disease. In addition, this protein has been shown to have an antimicrobial function, inhibiting the replication of herpes simplex virus. Alternative splicing results in multiple transcript variants encoding a single protein. [provided by RefSeq, Nov 2014]



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