Human LIN28A/CSDD1/LIN-28 ORF/cDNA clone-Lentivirus plasmid (NM_024674.5)

Cat. No.: pGMLV000061
Size: 10 µg
Concentration: generally 0.5ug/ul, usually not less than 0.3ug/ul
Leading Time: 3-7 working days

Pre-made Human LIN28A/CSDD1/LIN-28 Lentiviral expression plasmid for LIN28A lentivirus packaging, LIN28A lentivirus production, overexpression stable cell line development, cell transient transfection and gene delivery targeting T/B/NK cells, macrophages, cardiomyocytes, hepatocytes, and neurons.

Our GM-Lentiviral vector is seamlessly integrated with the GM lentivirus packaging system. Discover more about the GM lentivirus packaging system.

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Product Description

Catalog ID pGMLV000061
Gene Name LIN28A
Accession Number NM_024674.5
Gene ID 79727
Species Human
Product Type Lentivirus plasmid (overexpression)
Insert Length 630 bp
Gene Alias CSDD1,LIN-28,lin-28A,LIN28,ZCCHC1
Fluorescent Reporter ZsGreen
Mammalian Cell Selection Puromyocin
Fusion Tag 3xflag (C-Terminal)
Promoter CMV
Resistance Amplicin
ORF Nucleotide Sequence ATGGGCTCCGTGTCCAACCAGCAGTTTGCAGGTGGCTGCGCCAAGGCGGCAGAAGAGGCGCCCGAGGAGGCGCCGGAGGACGCGGCCCGGGCGGCGGACGAGCCTCAGCTGCTGCACGGTGCGGGCATCTGTAAGTGGTTCAACGTGCGCATGGGGTTCGGCTTCCTGTCCATGACCGCCCGCGCCGGGGTCGCGCTCGACCCCCCAGTGGATGTCTTTGTGCACCAGAGTAAGCTGCACATGGAAGGGTTCCGGAGCTTGAAGGAGGGTGAGGCAGTGGAGTTCACCTTTAAGAAGTCAGCCAAGGGTCTGGAATCCATCCGTGTCACCGGACCTGGTGGAGTATTCTGTATTGGGAGTGAGAGGCGGCCAAAAGGAAAGAGCATGCAGAAGCGCAGATCAAAAGGAGACAGGTGCTACAACTGTGGAGGTCTAGATCATCATGCCAAGGAATGCAAGCTGCCACCCCAGCCCAAGAAGTGCCACTTCTGCCAGAGCATCAGCCATATGGTAGCCTCATGTCCGCTGAAGGCCCAGCAGGGCCCTAGTGCACAGGGAAAGCCAACCTACTTTCGAGAGGAAGAAGAAGAAATCCACAGCCCTACCCTGCTCCCGGAGGCACAGAATTGA
ORF Protein Sequence MGSVSNQQFAGGCAKAAEEAPEEAPEDAARAADEPQLLHGAGICKWFNVRMGFGFLSMTARAGVALDPPVDVFVHQSKLHMEGFRSLKEGEAVEFTFKKSAKGLESIRVTGPGGVFCIGSERRPKGKSMQKRRSKGDRCYNCGGLDHHAKECKLPPQPKKCHFCQSISHMVASCPLKAQQGPSAQGKPTYFREEEEEIHSPTLLPEAQN

Reference




    Data / case study


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    Associated products


    Category Cat No. Products Name
    Target Antibody GM-Tg-g-T49593-Ab Anti-Lin-28A monoclonal antibody
    Target Antigen GM-Tg-g-T49593-Ag Lin-28A/LIN28A protein
    ORF Viral Vector pGMLV000061 Human LIN28A Lentivirus plasmid
    ORF Viral Vector pGMAP000263 Human LIN28 Adenovirus plasmid
    ORF Viral Vector pGMPC000178 Human lin28a Mammalian (Non-Viral Vector) plasmid
    ORF Viral Vector pGMPC001364 Human LIN28A Mammalian (Non-Viral Vector) plasmid
    ORF Viral Vector vGMLV000061 Human LIN28A Lentivirus particle
    ORF Viral Vector vGMAP000263 Human LIN28 Adenovirus particle


    Target information

    Target ID GM-T49593
    Target Name Lin-28A
    Gene ID 79727, 83557, 719865, 500562, 100379627, 102151926, 614997, 100071098
    Gene Symbol and Synonyms CSDD1,Gm10299,LIN-28,lin-28A,LIN28,LIN28A,RGD1566408,Tex17,ZCCHC1
    Uniprot Accession Q9H9Z2
    Uniprot Entry Name LN28A_HUMAN
    Protein Sub-location Introcelluar Protein
    Category Not Available
    Disease Not Available
    Gene Ensembl ENSG00000131914
    Target Classification Not Available

    This gene encodes a LIN-28 family RNA-binding protein that acts as a posttranscriptional regulator of genes involved in developmental timing and self-renewal in embryonic stem cells. The encoded protein functions through direct interaction with target mRNAs and by disrupting the maturation of certain miRNAs involved in embryonic development. This protein prevents the terminal processing of the LET7 family of microRNAs which are major regulators of cellular growth and differentiation. Aberrant expression of this gene is associated with cancer progression in multiple tissues. [provided by RefSeq, Sep 2015]



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