Human MECP2/AUTSX3/ MRX16 ORF/cDNA clone-Adenovirus particle (NM_004992.3)
Pre-made Human MECP2/AUTSX3/ MRX16 Adenovirus for MECP2 overexpression in-vitro and in-vivo. The MECP2 adenoviral vector excels as a vehicle for transient gene transfection in both stable cell lines and primary cells, including DC cells, macrophages, cardiomyocytes, hepatocytes, and neurons. The purified MECP2-encoding adenovirus also stands out as a quintessential tool for in vivo studies and vaccine research initiatives.
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Product information
Catalog No. | Product Name | Adenovirus Grade | Adenovirus quantity |
vGMAD000175 | Human MECP2 Adenovirus particle | Research Grade-In vitro | 1E+10PFU (1E+10pfu/ml×1ml) |
5E+10PFU (1E+10pfu/ml×5ml) | |||
1E+11PFU (1E+10pfu/ml×10ml) | |||
Research Grade-In vivo | 1E+11PFU (1E+11pfu/ml×1ml) | ||
GMP-like Grade | inquiry | ||
GMP Grade | inquiry |
Product Description
Catalog ID | vGMAD000175 |
Gene Name | MECP2 |
Accession Number | NM_004992.3 |
Gene ID | 4204 |
Species | Human |
Product Type | Adenovirus particle (overexpression) |
Insert Length | 1461 bp |
Gene Alias | AUTSX3, MRX16, MRX79, MRXS13, MRXSL, PPMX, RS, RTS, RTT |
Fluorescent Reporter | |
Mammalian Cell Selection | Null |
Fusion Tag | 3xflag (C-Terminal) |
Promoter | CMV |
Resistance | Amplicin |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Category | Cat No. | Products Name |
---|---|---|
Target Antibody | GM-Tg-g-T59686-Ab | Anti-MECP2 monoclonal antibody |
Target Antigen | GM-Tg-g-T59686-Ag | MECP2 protein |
ORF Viral Vector | pGMAD000175 | Human MECP2 Adenovirus plasmid |
ORF Viral Vector | pGMPC000469 | Human MECP2 Mammalian (Non-Viral Vector) plasmid |
ORF Viral Vector | pGMAP000464 | Human MECP2 Adenovirus plasmid |
ORF Viral Vector | vGMAD000175 | Human MECP2 Adenovirus particle |
ORF Viral Vector | vGMAP000464 | Human MECP2 Adenovirus particle |
Target information
Target ID | GM-T59686 |
Target Name | MECP2 |
Gene ID | 4204, 17257, 700174, 29386, 101082385, 612973, 539629, 100058125 |
Gene Symbol and Synonyms | 1500041B07Rik,AUTSX3,D630021H01Rik,Mbd5,MECP2,MRX16,MRX79,MRXS13,MRXSL,PPMX,RS,RTS,RTT,WBP10 |
Uniprot Accession | P51608 |
Uniprot Entry Name | MECP2_HUMAN |
Protein Sub-location | Introcelluar Protein |
Category | Therapeutics Target |
Disease | Cancer |
Gene Ensembl | ENSG00000169057 |
Target Classification | Tumor-associated antigen (TAA) |
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of cognitive disability in females. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2015]
About GMVC
GMVC (GM Vector Core) is GeneMedi’s unique platform for QbD Viral vectors Processes development and manufacturing. In GMVC, our core expertise lies in the tailored production of viral vectors, including adeno-associated virus (AAV), lentivirus, and adenovirus. Our state-of-the-art facilities are equipped for scalable manufacturing, ensuring high-quality viral vector production to meet both research and therapeutic needs. Our expert team specializes in process development, leveraging innovative technology and extensive industry knowledge to provide clients with tailored solutions that exceed expectations. GMVC will be the ideal partner for scientists and healthcare professionals seeking reliable and efficient viral vector production services.