Anti-FKBP1A monoclonal antibody

Pre-made anti-FKBP1A monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research

Target products collectionGo to FKBP1A/FKBP1A products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-IP0019-Ab-1/ GM-Tg-hg-IP0019-Ab-2Anti-Human FKBP1A monoclonal antibodyHuman
GM-Tg-rg-IP0019-Ab-1/ GM-Tg-rg-IP0019-Ab-2Anti-Rat FKBP1A monoclonal antibodyRat
GM-Tg-mg-IP0019-Ab-1/ GM-Tg-mg-IP0019-Ab-2Anti-Mouse FKBP1A monoclonal antibodyMouse
GM-Tg-cynog-IP0019-Ab-1/ GM-Tg-cynog-IP0019-Ab-2Anti-Cynomolgus/ Rhesus macaque FKBP1A monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-IP0019-Ab-1/ GM-Tg-felg-IP0019-Ab-2Anti-Feline FKBP1A monoclonal antibodyFeline
GM-Tg-cang-IP0019-Ab-1/ GM-Tg-cang-IP0019-Ab-2Anti-Canine FKBP1A monoclonal antibodyCanine
GM-Tg-bovg-IP0019-Ab-1/ GM-Tg-bovg-IP0019-Ab-2Anti-Bovine FKBP1A monoclonal antibodyBovine
GM-Tg-equg-IP0019-Ab-1/ GM-Tg-equg-IP0019-Ab-2Anti-Equine FKBP1A monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-IP0019-Ab-1/ GM-Tg-hg-IP0019-Ab-2; GM-Tg-rg-IP0019-Ab-1/ GM-Tg-rg-IP0019-Ab-2;
GM-Tg-mg-IP0019-Ab-1/ GM-Tg-mg-IP0019-Ab-2; GM-Tg-cynog-IP0019-Ab-1/ GM-Tg-cynog-IP0019-Ab-2;
GM-Tg-felg-IP0019-Ab-1/ GM-Tg-felg-IP0019-Ab-2; GM-Tg-cang-IP0019-Ab-1/ GM-Tg-cang-IP0019-Ab-2;
GM-Tg-bovg-IP0019-Ab-1/ GM-Tg-bovg-IP0019-Ab-2; GM-Tg-equg-IP0019-Ab-1/ GM-Tg-equg-IP0019-Ab-2
Products NameAnti-FKBP1A monoclonal antibody
Formatmab
Target NameFKBP1A
Protein Sub-locationIntrocelluar Protein
Category of antibodyTherapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected.
TagFc
Products descriptionPre-made anti-FKBP1A monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-IP0019-Ag-1Recombinant multi-species FKB1A/ FKBP1A/ FKBP-12 protein
    ORF Viral VectorpGMLP000449human FKBP1A Lentivirus plasmid
    ORF Viral VectorvGMLP000449human FKBP1A Lentivirus particle
    ORF Viral VectorvGMAP000487Human FKBP1A Adenovirus particle
    ORF Viral VectorvGMAP000355Human FKBP1A Adenovirus particle
    ORF Viral VectorpGMAP000355Human FKBP1A Adenovirus plasmid
    ORF Viral VectorpGMAP000487Human FKBP1A Adenovirus plasmid
    ORF Viral VectorpGMLPm000087mouse Fkbp1a Lentivirus plasmid
    ORF Viral VectorvGMLPm000087mouse Fkbp1a Lentivirus particle


    Target information

    Target IDGM-IP0019
    Target NameFKBP1A
    Gene ID2280,14225,25639,717385,100686033,101100379,614795,100629541
    Gene Symbol and SynonymsFkbp,FKBP-12,FKBP-1A,FKBP1,FKBP12,FKBP1A,FKBP1B,Fkbp2,PKC12,PKCI2,PPIASE
    Uniprot AccessionP62942,Q62658,P18203
    Uniprot Entry NameFKB1A_HUMAN,FKB1A_RAT,FKB1A_BOVIN
    Protein Sub-locationIntrocelluar Protein
    CategoryTherapeutics Target
    DiseaseN/A
    Gene EnsemblENSG00000088832
    Target ClassificationN/A

    The target: FKBP1A, gene name: FKBP1A, also named as FKBP-12, FKBP-1A, FKBP1, FKBP12, PKC12, PKCI2, PPIASE. The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse, deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium. Multiple alternatively spliced variants, encoding the same protein, have been identified. The human genome contains five pseudogenes related to this gene, at least one of which is transcribed. [provided by RefSeq, Sep 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.