Recombinant multi-species FKB1A/ FKBP1A/ FKBP-12 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine FKBP1A protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

The target: FKBP1A, gene name: FKBP1A, also named as FKBP-12, FKBP-1A, FKBP1, FKBP12, PKC12, PKCI2, PPIASE. The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse, deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium. Multiple alternatively spliced variants, encoding the same protein, have been identified. The human genome contains five pseudogenes related to this gene, at least one of which is transcribed. [provided by RefSeq, Sep 2008].

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Catalog No.	Product Name	Species	Size	Price
GM-Tg-hg-IP0019-Ag-1	Human FKBP1A protein	Human	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-rg-IP0019-Ag-1	Rat FKBP1A protein	Rat	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-mg-IP0019-Ag-1	Mouse FKBP1A protein	Mouse	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-cynog-IP0019-Ag-1	Cynomolgus/ Rhesus macaque FKBP1A protein	Cynomolgus/ Rhesus macaque	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-felg-IP0019-Ag-1	Feline FKBP1A protein	Feline	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-cang-IP0019-Ag-1	Canine FKBP1A protein	Canine	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-bovg-IP0019-Ag-1	Bovine FKBP1A protein	Bovine	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-bovg-IP0019-Ag-1	Equine FKBP1A protein	Equine	1mg/10mg/100mg/≥100mg	Inquiry
Shipping Cost:				760.00

Description

Catalog No.	GM-Tg-hg-IP0019-Ag, GM-Tg-rg-IP0019-Ag, GM-Tg-mg-IP0019-Ag, GM-Tg-cynog-IP0019-Ag, GM-Tg-felg-IP0019-Ag, GM-Tg-cang-IP0019-Ag, GM-Tg-bovg-IP0019-Ag, GM-Tg-equg-IP0019-Ag-1
Products Name	FKBP1A protein
Species	Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name	FKBP1A
Protein Sub-location	Introcelluar Protein
Isotypes	Recombinant protein
Expression platform	Mammalian cell
Bioactivity validation	Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag	His
Products description	Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine FKBP1A protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity	Purity: ≥95% (SDS-PAGE)
Application	In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation	Supplied as a 0.2 μM filtered solution of PBS, PH7.4.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.