Anti-SYK/ KARS/ CMTRIB monoclonal antibody

Anti-SYK/ KARS/ CMTRIB antibody for FACS & in-vivo assay

Target products collectionGo to KARS/KARS products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP2574-Ab-1/ GM-Tg-hg-MP2574-Ab-2Anti-Human KARS monoclonal antibodyHuman
GM-Tg-rg-MP2574-Ab-1/ GM-Tg-rg-MP2574-Ab-2Anti-Rat KARS monoclonal antibodyRat
GM-Tg-mg-MP2574-Ab-1/ GM-Tg-mg-MP2574-Ab-2Anti-Mouse KARS monoclonal antibodyMouse
GM-Tg-cynog-MP2574-Ab-1/ GM-Tg-cynog-MP2574-Ab-2Anti-Cynomolgus/ Rhesus macaque KARS monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP2574-Ab-1/ GM-Tg-felg-MP2574-Ab-2Anti-Feline KARS monoclonal antibodyFeline
GM-Tg-cang-MP2574-Ab-1/ GM-Tg-cang-MP2574-Ab-2Anti-Canine KARS monoclonal antibodyCanine
GM-Tg-bovg-MP2574-Ab-1/ GM-Tg-bovg-MP2574-Ab-2Anti-Bovine KARS monoclonal antibodyBovine
GM-Tg-equg-MP2574-Ab-1/ GM-Tg-equg-MP2574-Ab-2Anti-Equine KARS monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg

Product Description

Catalog No.GM-Tg-hg-MP2574-Ab-1/ GM-Tg-hg-MP2574-Ab-2; GM-Tg-rg-MP2574-Ab-1/ GM-Tg-rg-MP2574-Ab-2;
GM-Tg-mg-MP2574-Ab-1/ GM-Tg-mg-MP2574-Ab-2; GM-Tg-cynog-MP2574-Ab-1/ GM-Tg-cynog-MP2574-Ab-2;
GM-Tg-felg-MP2574-Ab-1/ GM-Tg-felg-MP2574-Ab-2; GM-Tg-cang-MP2574-Ab-1/ GM-Tg-cang-MP2574-Ab-2;
GM-Tg-bovg-MP2574-Ab-1/ GM-Tg-bovg-MP2574-Ab-2; GM-Tg-equg-MP2574-Ab-1/ GM-Tg-equg-MP2574-Ab-2
Products NameAnti-KARS monoclonal antibody
Target NameKARS
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
Products descriptionPre-made anti-KARS benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


    Data / case study

    Click to get more Data / Case study about the product.

    Associated products

    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species SYK/ KARS/ CMTRIB VLP (virus-like particle) (Products Developing)
    ORF Viral VectorpGMLP005103human KARS Lentivirus plasmid
    ORF Viral VectorvGMLP005103human KARS Lentivirus particle

    Target information

    Target IDGM-MP2574
    Target NameKARS
    Gene ID3735,85305,292028,714516,479644,101092570,509624,100055335
    Gene Symbol and SynonymsCMTRIB,D8Ertd698e,D8Wsu108e,DEAPLE,DFNB89,KARS,KARS1,KARS2,KRS,LEPID,LysRS,mKIAA0070
    Uniprot AccessionQ15046,Q5XIM7
    Uniprot Entry NameSYK_HUMAN,SYK_RAT
    Protein Sub-locationTransmembrane Protein
    Gene EnsemblENSG00000065427
    Target ClassificationN/A

    The target: KARS, gene name: KARS, also named as CMTRIB, DFNB891, KARS2, KRS, KARS. Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Lysyl-tRNA synthetase is a homodimer localized to the cytoplasm which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

    About Gmab


    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.