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Anti-FXR monoclonal antibody
Pre-made anti-FXR monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to FXR/NR1H4 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T51426-Ab-1/ GM-Tg-hg-T51426-Ab-2 | Anti-Human FXR/NR1H4 monoclonal antibody | Human |
| GM-Tg-rg-T51426-Ab-1/ GM-Tg-rg-T51426-Ab-2 | Anti-Rat FXR/NR1H4 monoclonal antibody | Rat |
| GM-Tg-mg-T51426-Ab-1/ GM-Tg-mg-T51426-Ab-2 | Anti-Mouse FXR/NR1H4 monoclonal antibody | Mouse |
| GM-Tg-cynog-T51426-Ab-1/ GM-Tg-cynog-T51426-Ab-2 | Anti-Cynomolgus/ Rhesus macaque FXR/NR1H4 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T51426-Ab-1/ GM-Tg-felg-T51426-Ab-2 | Anti-Feline FXR/NR1H4 monoclonal antibody | Feline |
| GM-Tg-cang-T51426-Ab-1/ GM-Tg-cang-T51426-Ab-2 | Anti-Canine FXR/NR1H4 monoclonal antibody | Canine |
| GM-Tg-bovg-T51426-Ab-1/ GM-Tg-bovg-T51426-Ab-2 | Anti-Bovine FXR/NR1H4 monoclonal antibody | Bovine |
| GM-Tg-equg-T51426-Ab-1/ GM-Tg-equg-T51426-Ab-2 | Anti-Equine FXR/NR1H4 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T51426-Ab-1/ GM-Tg-hg-T51426-Ab-2; GM-Tg-rg-T51426-Ab-1/ GM-Tg-rg-T51426-Ab-2; GM-Tg-mg-T51426-Ab-1/ GM-Tg-mg-T51426-Ab-2; GM-Tg-cynog-T51426-Ab-1/ GM-Tg-cynog-T51426-Ab-2; GM-Tg-felg-T51426-Ab-1/ GM-Tg-felg-T51426-Ab-2; GM-Tg-cang-T51426-Ab-1/ GM-Tg-cang-T51426-Ab-2; GM-Tg-bovg-T51426-Ab-1/ GM-Tg-bovg-T51426-Ab-2; GM-Tg-equg-T51426-Ab-1/ GM-Tg-equg-T51426-Ab-2 |
| Products Name | Anti-FXR/NR1H4 monoclonal antibody |
| Format | mab |
| Target Name | FXR |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-FXR monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T51426-Ag-1 | Recombinant multi-species NR1H4/ FXR/ BAR protein |
| ORF Viral Vector | pGMAD000635 | house mouse Nr1h4 Adenovirus plasmid |
| ORF Viral Vector | pGMAAV000015 | mouse Nr1h4 AAV plasmid |
| ORF Viral Vector | pGMAAV000319 | house mouse Nr1h4 AAV plasmid |
| ORF Viral Vector | vGMAD000635 | house mouse Nr1h4 Adenovirus particle |
| ORF Viral Vector | vGMAAV000015 | mouse Nr1h4 AAV particle |
| ORF Viral Vector | vGMAAV000319 | house mouse Nr1h4 AAV particle |
Target information
| Target ID | GM-T51426 |
| Target Name | FXR |
| Gene ID | 9971,20186,60351,695618,612928,101096997,540528,100052821 |
| Gene Symbol and Synonyms | BAR,FXR,HRR-1,HRR1,NR1H4,PFIC5,RIP14,Rxrip14 |
| Uniprot Accession | Q96RI1,Q62735,Q3SZL0 |
| Uniprot Entry Name | NR1H4_HUMAN,NR1H4_RAT,NR1H4_BOVIN |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000012504 |
| Target Classification | Nuclear Receptors |
The target: FXR, gene name: NR1H4, also named as BAR, FXR, HRR-1, HRR1, PFIC5, RIP14. This gene encodes a ligand-activated transcription factor that shares structural features in common with nuclear hormone receptor family members. This protein functions as a receptor for bile acids, and when bound to bile acids, binds to DNA and regulates the expression of genes involved in bile acid synthesis and transport. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Feb 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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