Recombinant multi-species NR1H4/ FXR/ BAR protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine FXR/NR1H4 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

The target: FXR, gene name: NR1H4, also named as BAR, FXR, HRR-1, HRR1, PFIC5, RIP14. This gene encodes a ligand-activated transcription factor that shares structural features in common with nuclear hormone receptor family members. This protein functions as a receptor for bile acids, and when bound to bile acids, binds to DNA and regulates the expression of genes involved in bile acid synthesis and transport. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Feb 2016].

Order information

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Catalog No.	Product Name	Species	Size	Price
GM-Tg-hg-T51426-Ag-1	Human FXR/NR1H4 protein	Human	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-rg-T51426-Ag-1	Rat FXR/NR1H4 protein	Rat	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-mg-T51426-Ag-1	Mouse FXR/NR1H4 protein	Mouse	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-cynog-T51426-Ag-1	Cynomolgus/ Rhesus macaque FXR/NR1H4 protein	Cynomolgus/ Rhesus macaque	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-felg-T51426-Ag-1	Feline FXR/NR1H4 protein	Feline	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-cang-T51426-Ag-1	Canine FXR/NR1H4 protein	Canine	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-bovg-T51426-Ag-1	Bovine FXR/NR1H4 protein	Bovine	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-bovg-T51426-Ag-1	Equine FXR/NR1H4 protein	Equine	1mg/10mg/100mg/≥100mg	Inquiry
Shipping Cost:				760.00

Description

Catalog No.	GM-Tg-hg-T51426-Ag, GM-Tg-rg-T51426-Ag, GM-Tg-mg-T51426-Ag, GM-Tg-cynog-T51426-Ag, GM-Tg-felg-T51426-Ag, GM-Tg-cang-T51426-Ag, GM-Tg-bovg-T51426-Ag, GM-Tg-equg-T51426-Ag-1
Products Name	FXR/NR1H4 protein
Species	Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name	FXR
Protein Sub-location	Introcelluar Protein
Isotypes	Recombinant protein
Expression platform	Mammalian cell
Bioactivity validation	Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag	His
Products description	Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine FXR/NR1H4 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity	Purity: ≥95% (SDS-PAGE)
Application	In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation	Supplied as a 0.2 μM filtered solution of PBS, PH7.4.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.