FXR/NR1H4: Target/Biomarker Introduction, products summarized (antibody/ADC/bispecific/antigen/ORF vector/VLP) and disease/indication/condition/MOA for drug discovery and IVD
It's the GeneMedi's summary page for Target/Biomarker Introduction of FXR/NR1H4. The page also collects GeneMedi's different modalities and formats products for FXR in therapeutics/drug discovery and IVD diagnostics, which is including antibody, ADC, bispecific, antigen, ORF vector, VLP, etc. With GeneMedi's target-insight database-GM ITD database, the FXR target is also connected to human indications/diseases/conditions/MOA.
Target sublocation: Introcelluar Protein.
This gene encodes a ligand-activated transcription factor that shares structural features in common with nuclear hormone receptor family members. This protein functions as a receptor for bile acids, and when bound to bile acids, binds to DNA and regulates the expression of genes involved in bile acid synthesis and transport. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Feb 2016]
Target ID | GM-T51426 |
Target Name | FXR |
Gene ID | 9971,20186,60351,695618,612928,101096997,540528,100052821 |
Gene Symbol and Synonyms | BAR,FXR,HRR-1,HRR1,NR1H4,PFIC5,RIP14,Rxrip14 |
Uniprot Accession | Q96RI1,Q62735,Q3SZL0 |
Uniprot Entry Name | NR1H4_HUMAN,NR1H4_RAT,NR1H4_BOVIN |
Protein Sub-location | Introcelluar Protein |
Category | Therapeutics Target |
Disease | N/A |
Gene Ensembl | ENSG00000012504 |
Target Classification | Nuclear Receptors |
Pre-made anti-FXR inhibitory monoclonal antibody(mab, blocking antibody inhibitor)-benchmark antibody for drug discovery and mechanism of action (MOA) research
Pre-made anti-FXR monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). The anti-FXR mab is expressed and produced by mammalian cell line as a benchmark reference therapeutic antibody for biological drug discovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Antibody Name | Species | Format | Classified by tag | Detail |
Anti-FXR/NR1H4 monoclonal antibody | Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine | mab | Therapeutics Target antibody | Detail |
Recombinant multi-species NR1H4/ FXR/ BAR protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis
Genemedi produces Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine FXR/NR1H4 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
Products Name | Species | Expression Platform | Detail |
FXR/NR1H4 protein | Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine | Mammalian cell | Detail |
Pre-made NR1H4 viral vector in GM Promise-ORFTM
Cat No. | Products name | NM ID | Species | Type | Detail |
pGMAD000635 | house mouse Nr1h4 Adenovirus plasmid | NM_001163700 | House Mouse | Adenovirus plasmid | Detail |
pGMAAV000015 | mouse Nr1h4 AAV plasmid | NM_001163700.1 | Mouse | AAV plasmid | Detail |
pGMAAV000319 | house mouse Nr1h4 AAV plasmid | NM_001163700.1 | House Mouse | AAV plasmid | Detail |
vGMAD000635 | house mouse Nr1h4 Adenovirus particle | NM_001163700 | House Mouse | Adenovirus particle | Detail |
vGMAAV000015 | mouse Nr1h4 AAV particle | NM_001163700.1 | Mouse | AAV particle | Detail |
vGMAAV000319 | house mouse Nr1h4 AAV particle | NM_001163700.1 | House Mouse | AAV particle | Detail |
About Promise-ORFTM:
Discover the largest collection of ORF/cDNA expression clones from different species, including human, mouse, rat, and more with GeneMedi's Promise-ORFTM. Our collection of ORFs expression clones come in verified mammalian or viral vectors lentivirus, AAV, and adenovirus) and our Promise-ORFTM viral-ready expression vectors make it easy for you to improve viral vector packaging efficiency or directly transfect mammalian cells, resulting in stronger and easier expression detection. Click to search your GOI
If you want to obtain higher quantities of plasmids (mg), please visit GM TransExcellent Plasmid DNA Rapid Preparation Service.