Anti-NR1I3 monoclonal antibody
Pre-made anti-NR1I3 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
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(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
Product information
Catalog No. | Product Name | Species Reactivity |
---|---|---|
GM-Tg-hg-T69506-Ab-1/ GM-Tg-hg-T69506-Ab-2 | Anti-Human NR1I3 monoclonal antibody | Human |
GM-Tg-rg-T69506-Ab-1/ GM-Tg-rg-T69506-Ab-2 | Anti-Rat NR1I3 monoclonal antibody | Rat |
GM-Tg-mg-T69506-Ab-1/ GM-Tg-mg-T69506-Ab-2 | Anti-Mouse NR1I3 monoclonal antibody | Mouse |
GM-Tg-cynog-T69506-Ab-1/ GM-Tg-cynog-T69506-Ab-2 | Anti-Cynomolgus/ Rhesus macaque NR1I3 monoclonal antibody | Cynomolgus/ Rhesus macaque |
GM-Tg-felg-T69506-Ab-1/ GM-Tg-felg-T69506-Ab-2 | Anti-Feline NR1I3 monoclonal antibody | Feline |
GM-Tg-cang-T69506-Ab-1/ GM-Tg-cang-T69506-Ab-2 | Anti-Canine NR1I3 monoclonal antibody | Canine |
GM-Tg-bovg-T69506-Ab-1/ GM-Tg-bovg-T69506-Ab-2 | Anti-Bovine NR1I3 monoclonal antibody | Bovine |
GM-Tg-equg-T69506-Ab-1/ GM-Tg-equg-T69506-Ab-2 | Anti-Equine NR1I3 monoclonal antibody | Equine |
Size: 1mg | 10mg | 100mg
Product Description
Catalog No. | GM-Tg-hg-T69506-Ab-1/ GM-Tg-hg-T69506-Ab-2; GM-Tg-rg-T69506-Ab-1/ GM-Tg-rg-T69506-Ab-2; GM-Tg-mg-T69506-Ab-1/ GM-Tg-mg-T69506-Ab-2; GM-Tg-cynog-T69506-Ab-1/ GM-Tg-cynog-T69506-Ab-2; GM-Tg-felg-T69506-Ab-1/ GM-Tg-felg-T69506-Ab-2; GM-Tg-cang-T69506-Ab-1/ GM-Tg-cang-T69506-Ab-2; GM-Tg-bovg-T69506-Ab-1/ GM-Tg-bovg-T69506-Ab-2; GM-Tg-equg-T69506-Ab-1/ GM-Tg-equg-T69506-Ab-2 |
Products Name | Anti-NR1I3 monoclonal antibody |
Format | mab |
Target Name | NR1I3 |
Protein Sub-location | Introcelluar Protein |
Category of antibody | Therapeutics Target antibody |
Derivation (species) | Mouse |
CH1+2+3 Isotype (Receptor identification) | IgG |
Type of Light Chain (VD-LC) | N/A |
Expression platform | Mammalian Expression |
Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
Tag | Fc |
Products description | Pre-made anti-NR1I3 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Category | Cat No. | Products Name |
Target Antigen | GM-Tg-g-T69506-Ag-1 | Recombinant multi-species NR1I3/ CAR/ CAR1 protein |
ORF Viral Vector | vGMAD000501 | human NR1I3 Adenovirus particle |
ORF Viral Vector | vGMLP002652 | human NR1I3 Lentivirus particle |
ORF Viral Vector | vGMAP000504 | Human NR1I3 Adenovirus particle |
ORF Viral Vector | pGMAD000501 | human NR1I3 Adenovirus plasmid |
ORF Viral Vector | pGMAP000504 | Human NR1I3 Adenovirus plasmid |
ORF Viral Vector | pGMLP002652 | human NR1I3 Lentivirus plasmid |
ORF Viral Vector | pGMLPm001844 | mouse Nr1i3 Lentivirus plasmid |
ORF Viral Vector | vGMLPm001844 | mouse Nr1i3 Lentivirus particle |
Target information
Target ID | GM-T69506 |
Target Name | NR1I3 |
Gene ID | 9970,12355,65035,574249,488653,101088457,493711,100066015 |
Gene Symbol and Synonyms | CAR,CAR-beta,CAR1,Care2,ES™32,MB67,NR1I3 |
Uniprot Accession | Q14994,Q9QUS1,Q8MIM3 |
Uniprot Entry Name | NR1I3_HUMAN,NR1I3_MACMU,NR1I3_RAT |
Protein Sub-location | Introcelluar Protein |
Category | Therapeutics Target |
Disease | N/A |
Gene Ensembl | ENSG00000143257 |
Target Classification | N/A |
The target: NR1I3, gene name: NR1I3, also named as CAR, CAR1, MB67. This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. In addition to drug metabolism, the CAR protein is also reported to regulate genes involved in glucose metabolism, lipid metabolism, cell proliferation, and circadian clock regulation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2020].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.