Recombinant multi-species NR1I3/ CAR/ CAR1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine NR1I3 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

The target: NR1I3, gene name: NR1I3, also named as CAR, CAR1, MB67. This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. In addition to drug metabolism, the CAR protein is also reported to regulate genes involved in glucose metabolism, lipid metabolism, cell proliferation, and circadian clock regulation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2020].

Order information

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Catalog No.	Product Name	Species	Size	Price
GM-Tg-hg-T69506-Ag-1	Human NR1I3 protein	Human	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-rg-T69506-Ag-1	Rat NR1I3 protein	Rat	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-mg-T69506-Ag-1	Mouse NR1I3 protein	Mouse	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-cynog-T69506-Ag-1	Cynomolgus/ Rhesus macaque NR1I3 protein	Cynomolgus/ Rhesus macaque	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-felg-T69506-Ag-1	Feline NR1I3 protein	Feline	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-cang-T69506-Ag-1	Canine NR1I3 protein	Canine	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-bovg-T69506-Ag-1	Bovine NR1I3 protein	Bovine	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-bovg-T69506-Ag-1	Equine NR1I3 protein	Equine	1mg/10mg/100mg/≥100mg	Inquiry
Shipping Cost:				760.00

Description

Catalog No.	GM-Tg-hg-T69506-Ag, GM-Tg-rg-T69506-Ag, GM-Tg-mg-T69506-Ag, GM-Tg-cynog-T69506-Ag, GM-Tg-felg-T69506-Ag, GM-Tg-cang-T69506-Ag, GM-Tg-bovg-T69506-Ag, GM-Tg-equg-T69506-Ag-1
Products Name	NR1I3 protein
Species	Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name	NR1I3
Protein Sub-location	Introcelluar Protein
Isotypes	Recombinant protein
Expression platform	Mammalian cell
Bioactivity validation	Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag	His
Products description	Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine NR1I3 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity	Purity: ≥95% (SDS-PAGE)
Application	In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation	Supplied as a 0.2 μM filtered solution of PBS, PH7.4.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.