NR1I3: Target/Biomarker Introduction, products summarized (antibody/ADC/bispecific/antigen/ORF vector/VLP) and disease/indication/condition/MOA for drug discovery and IVD
It's the GeneMedi's summary page for Target/Biomarker Introduction of NR1I3. The page also collects GeneMedi's different modalities and formats products for NR1I3 in therapeutics/drug discovery and IVD diagnostics, which is including antibody, ADC, bispecific, antigen, ORF vector, VLP, etc. With GeneMedi's target-insight database-GM ITD database, the NR1I3 target is also connected to human indications/diseases/conditions/MOA.
Target sublocation: Introcelluar Protein.
This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. In addition to drug metabolism, the CAR protein is also reported to regulate genes involved in glucose metabolism, lipid metabolism, cell proliferation, and circadian clock regulation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2020]
Target ID | GM-T69506 |
Target Name | NR1I3 |
Gene ID | 9970,12355,65035,574249,488653,101088457,493711,100066015 |
Gene Symbol and Synonyms | CAR,CAR-beta,CAR1,Care2,ESTM32,MB67,NR1I3 |
Uniprot Accession | Q14994,Q9QUS1,Q8MIM3 |
Uniprot Entry Name | NR1I3_HUMAN,NR1I3_MACMU,NR1I3_RAT |
Protein Sub-location | Introcelluar Protein |
Category | Therapeutics Target |
Disease | N/A |
Gene Ensembl | ENSG00000143257 |
Target Classification | N/A |
Pre-made anti-NR1I3 inhibitory monoclonal antibody(mab, blocking antibody inhibitor)-benchmark antibody for drug discovery and mechanism of action (MOA) research
Pre-made anti-NR1I3 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). The anti-NR1I3 mab is expressed and produced by mammalian cell line as a benchmark reference therapeutic antibody for biological drug discovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Antibody Name | Species | Format | Classified by tag | Detail |
Anti-NR1I3 monoclonal antibody | Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine | mab | Therapeutics Target antibody | Detail |
Recombinant multi-species NR1I3/ CAR/ CAR1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis
Genemedi produces Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine NR1I3 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
Products Name | Species | Expression Platform | Detail |
NR1I3 protein | Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine | Mammalian cell | Detail |
Pre-made NR1I3 viral vector in GM Promise-ORFTM
Cat No. | Products name | NM ID | Species | Type | Detail |
vGMAD000501 | human NR1I3 Adenovirus particle | NM_001077482 | Human | Adenovirus particle | Detail |
vGMLP002652 | human NR1I3 Lentivirus particle | NM_001077482 | Human | Lentivirus particle | Detail |
vGMAP000504 | Human NR1I3 Adenovirus particle | BC069626 | Human | Adenovirus particle | Detail |
pGMAD000501 | human NR1I3 Adenovirus plasmid | NM_001077482 | Human | Adenovirus plasmid | Detail |
pGMAP000504 | Human NR1I3 Adenovirus plasmid | BC069626 | Human | Adenovirus plasmid | Detail |
pGMLP002652 | human NR1I3 Lentivirus plasmid | NM_001077482 | Human | Lentivirus plasmid | Detail |
pGMLPm001844 | mouse Nr1i3 Lentivirus plasmid | NM_009803 | Mouse | Lentivirus plasmid | Detail |
vGMLPm001844 | mouse Nr1i3 Lentivirus particle | NM_009803 | Mouse | Lentivirus particle | Detail |
About Promise-ORFTM:
Discover the largest collection of ORF/cDNA expression clones from different species, including human, mouse, rat, and more with GeneMedi's Promise-ORFTM. Our collection of ORFs expression clones come in verified mammalian or viral vectors lentivirus, AAV, and adenovirus) and our Promise-ORFTM viral-ready expression vectors make it easy for you to improve viral vector packaging efficiency or directly transfect mammalian cells, resulting in stronger and easier expression detection. Click to search your GOI
If you want to obtain higher quantities of plasmids (mg), please visit GM TransExcellent Plasmid DNA Rapid Preparation Service.