IL22RA1: Target/Biomarker Introduction, products summarized (antibody/ADC/bispecific/antigen/ORF vector/VLP) and disease/indication/condition/MOA for drug discovery and IVD

It's the GeneMedi's summary page for Target/Biomarker Introduction of IL22RA1. The page also collects GeneMedi's different modalities and formats products for IL22RA1 in therapeutics/drug discovery and IVD diagnostics, which is including antibody, ADC, bispecific, antigen, ORF vector, VLP, etc. With GeneMedi's target-insight database-GM ITD database, the IL22RA1 target is also connected to human indications/diseases/conditions/MOA.

Target sublocation: Transmembrane Protein.

The protein encoded by this gene belongs to the class II cytokine receptor family, and has been shown to be a receptor for interleukin 22 (IL22). IL22 receptor is a protein complex that consists of this protein and interleukin 10 receptor, beta (IL10BR/CRFB4), a subunit also shared by the receptor complex for interleukin 10 (IL10). This gene and interleukin 28 receptor, alpha (IL28RA) form a cytokine receptor gene cluster in the chromosomal region 1p36. [provided by RefSeq, Jul 2008]

Target IDGM-MP0625
Target NameIL22RA1
Gene ID58985,230828,362629,719264,612279,101100741,508044,100071510
Gene Symbol and Synonyms9130219A07Rik,CRF2-9,IL-22R,IL22R,IL22R1,IL22RA1,RGD1559655
Uniprot AccessionQ8N6P7,Q3SYS8
Uniprot Entry NameI22R1_HUMAN,I22R1_BOVIN
Protein Sub-locationTransmembrane Protein
CategoryTherapeutics Target, INN Index, Cytokine Target
DiseaseN/A
Gene EnsemblENSG00000142677
Target ClassificationN/A


Pre-made IL22RA1-specific INN-index biosimilar (antibody&conjugates)

Anti-IL22RA1 therapeutic INN-index antibodies and conjugates are biosimilars expressed by mammalian cell line as a benchmark reference therapeutic antibody for drug discovery, target MOA research, cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).

Cat No.Products Name (INN Index)INN Name Previous Name Target FormatDetail
GMP-Bios-INN-821Pre-Made Efmarodocokin Alfa Biosimilar, Fusion Protein targeting IL22RA1/IL22R1 fused with human IGHG4 Fc (Fragment constant): Recombinant therapeutic protein targeting CRF2-9efmarodocokin alfaIL22RA1/IL22R1Fusion ProteinDetail

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Pre-made anti-IL22RA1 inhibitory monoclonal antibody(mab, blocking antibody inhibitor)-benchmark antibody for drug discovery and mechanism of action (MOA) research

Pre-made anti-IL22RA1 benchmark inhibitory monoclonal antibody(mab, blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). The anti-IL22RA1 mab is expressed and produced by mammalian cell line as a benchmark reference therapeutic antibody for biological drug discovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.

Antibody NameSpeciesFormatClassified by tagDetail
Anti-IL22RA1 monoclonal antibodyHuman, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, EquinemabFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibodyDetail



Multi-species I22R1/ IL22RA1/ CRF2-9 VLP (virus-like particle) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine IL22RA1 VLP (virus-like particle) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Products NameSpeciesExpression PlatformDetail
IL22RA1 VLP (virus-like particle)Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, EquineMammalian cellProducts Developing



Cytokine Products for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces human, Cynomolgus/ Rhesus macaque, rat, mouse interleukin 22 receptor, alpha 1 (IL22RA1) His+Avi (Biotinylated) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Interleukin 22 receptor, alpha 1 is a protein that in humans is encoded by the IL22RA1 gene. The protein encoded by this gene belongs to the class II cytokine receptor family, and has been shown to be a receptor for interleukin 22 (IL22). IL22 receptor is a protein complex that consists of this protein and interleukin 10 receptor, beta (IL10RB/CRFB4), a subunit also shared by the receptor complex for interleukin 10 (IL10). This gene and interleukin 28 receptor, alpha (IL28RA) form a cytokine receptor gene cluster in the chromosomal region 1p36.

TargetSpeciesAntigen Product NameBioactivity validation of AntigenAntibody Product NameBioactivity validation of AntibodiesDetail
IL22RA1Human, Cynomolgus/Rhesus macaque, rat, mouseinterleukin 22 receptor, alpha 1 (IL22RA1) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IL22RA1 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Detail

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Pre-made IL22RA1 viral vector in GM Promise-ORFTM

Cat No.Products nameNM IDSpeciesTypeDetail
pGMLV000689human IL22RA1 Lentivirus plasmidNM_021258.4HumanLentivirus plasmidDetail
vGMLV000689human IL22RA1 Lentivirus particleNM_021258.4HumanLentivirus particleDetail
vGMAD000641human IL22RA1 Adenovirus particleNM_021258.3HumanAdenovirus particleDetail
pGMAD000641human IL22RA1 Adenovirus plasmidNM_021258.3HumanAdenovirus plasmidDetail
pGMLPm005362mouse Il22ra1 Lentivirus plasmidNM_178257.2MouseLentivirus plasmidDetail
vGMLPm005362mouse Il22ra1 Lentivirus particleNM_178257.2MouseLentivirus particleDetail

About Promise-ORFTM:
Discover the largest collection of ORF/cDNA expression clones from different species, including human, mouse, rat, and more with GeneMedi's Promise-ORFTM. Our collection of ORFs expression clones come in verified mammalian or viral vectors lentivirus, AAV, and adenovirus) and our Promise-ORFTM viral-ready expression vectors make it easy for you to improve viral vector packaging efficiency or directly transfect mammalian cells, resulting in stronger and easier expression detection. Click to search your GOI

If you want to obtain higher quantities of plasmids (mg), please visit GM TransExcellent Plasmid DNA Rapid Preparation Service.






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