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It's the GeneMedi's summary page for Target/Biomarker Introduction of RAPGEF5. The page also collects GeneMedi's different modalities and formats products for RAPGEF5 in therapeutics/drug discovery and IVD diagnostics, which is including antibody, ADC, bispecific, antigen, ORF vector, VLP, etc. With GeneMedi's target-insight database-GM ITD database, the RAPGEF5 target is also connected to human indications/diseases/conditions/MOA.

Target sublocation: Transmembrane Protein.

Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF5, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008]

Target IDGM-MP2590
Target NameRAPGEF5
Gene ID9771
Gene Official NameRAPGEF5
Gene AliasGFR, MR-GEF, REPAC
Protein Sub-locationTransmembrane Protein
Categorynull


Pre-made anti-RAPGEF5 inhibitory monoclonal antibody(mab, blocking antibody inhibitor)-benchmark reference antibody for drug discovery and mechanism of action (MOA) research

Pre-made anti-RAPGEF5 benchmark inhibitory monoclonal antibody(mab, blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). The anti-RAPGEF5 mab is expressed and produced by mammalian cell line as a benchmark reference therapeutic antibody for biological drug discovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.

Cat No.Antibody NameFormatClassified by tagOrder
GM-Tg-hg-MP2590-AbAnti-RAPGEF5 monoclonal antibodymabBiofunctional antibodymonoclonal antibody.




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