SPP1: Target/Biomarker Introduction, products summarized (antibody/ADC/bispecific/antigen/ORF vector/VLP) and disease/indication/condition/MOA for drug discovery and IVD
It's the GeneMedi's summary page for Target/Biomarker Introduction of SPP1. The page also collects GeneMedi's different modalities and formats products for SPP1 in therapeutics/drug discovery and IVD diagnostics, which is including antibody, ADC, bispecific, antigen, ORF vector, VLP, etc. With GeneMedi's target-insight database-GM ITD database, the SPP1 target is also connected to human indications/diseases/conditions/MOA.
Target sublocation: Secreted Protein/Potential Cytokines.
The protein encoded by this gene is involved in the attachment of osteoclasts to the mineralized bone matrix. The encoded protein is secreted and binds hydroxyapatite with high affinity. The osteoclast vitronectin receptor is found in the cell membrane and may be involved in the binding to this protein. This protein is also a cytokine that upregulates expression of interferon-gamma and interleukin-12. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
| Target ID | GM-T00032 |
| Target Name | SPP1 |
| Gene ID | 6696,20750,25353,704930,478471,101094264,281499,100053029 |
| Gene Symbol and Synonyms | 2AR,Apl-1,BNSP,Bsp,BSPI,Eta,ETA-1,OP,OPN,Opnl,OSP,OST,Ric,Spp-1,SPP1 |
| Uniprot Accession | P10451,P08721,P31096 |
| Uniprot Entry Name | OSTP_HUMAN,OSTP_RAT,OSTP_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target |
| Disease | Ovarian cancer, Acute kidney failure, Asphyxia neonatorum, Calculus of kidney, Congenital occlusion of ureteropelvic junction, Contact with and (suspected) exposure to uranium, Dent disease, Hepatic fibrosis, Malignant neoplasm of bladder, Pregnant state, Sepsis |
| Gene Ensembl | ENSG00000118785 |
| Target Classification | N/A |
Pre-made anti-SPP1 inhibitory monoclonal antibody(mab, blocking antibody inhibitor)-benchmark antibody for drug discovery and mechanism of action (MOA) research
Pre-made anti-SPP1 benchmark inhibitory monoclonal antibody(mab, blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). The anti-SPP1 mab is expressed and produced by mammalian cell line as a benchmark reference therapeutic antibody for biological drug discovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
| Antibody Name | Species | Format | Classified by tag | Detail |
| Anti-SPP1 monoclonal antibody | Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
Recombinant multi-species OSTP/ SPP1/ BNSP protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis
Genemedi produces Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine SPP1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
| Products Name | Species | Expression Platform | Detail |
| SPP1 protein | Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine | Mammalian cell | Detail |
Pre-made SPP1 viral vector in GM Promise-ORFTM
| Cat No. | Products name | NM ID | Species | Type | Detail |
| vGMAP000451 | Human SPP1 Adenovirus particle | BC017387 | Human | Adenovirus particle | Detail |
| vGMAD000037 | human SPP1 Adenovirus particle | NM_001040058.1 | Human | Adenovirus particle | Detail |
| vGMLV000419 | human SPP1 Lentivirus particle | NM_001040058.1 | Human | Lentivirus particle | Detail |
| pGMAP000451 | Human SPP1 Adenovirus plasmid | BC017387 | Human | Adenovirus plasmid | Detail |
| pGMLV000419 | human SPP1 Lentivirus plasmid | NM_001040058.1 | Human | Lentivirus plasmid | Detail |
| vGMAD000016 | human SPP1 Adenovirus particle | NM_000582.2 | Human | Adenovirus particle | Detail |
| pGMAD000037 | human SPP1 Adenovirus plasmid | NM_001040058.1 | Human | Adenovirus plasmid | Detail |
| pGMAD000016 | human SPP1 Adenovirus plasmid | NM_000582.2 | Human | Adenovirus plasmid | Detail |
| pGMLPm000326 | mouse Spp1 Lentivirus plasmid | NM_009263 | Mouse | Lentivirus plasmid | Detail |
| vGMLPm000326 | mouse Spp1 Lentivirus particle | NM_009263 | Mouse | Lentivirus particle | Detail |
About Promise-ORFTM:
Discover the largest collection of ORF/cDNA expression clones from different species, including human, mouse, rat, and more with GeneMedi's Promise-ORFTM. Our collection of ORFs expression clones come in verified mammalian or viral vectors lentivirus, AAV, and adenovirus) and our Promise-ORFTM viral-ready expression vectors make it easy for you to improve viral vector packaging efficiency or directly transfect mammalian cells, resulting in stronger and easier expression detection. Click to search your GOI
If you want to obtain higher quantities of plasmids (mg), please visit GM TransExcellent Plasmid DNA Rapid Preparation Service.
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