INSR: Target/Biomarker Introduction, products summarized (antibody/ADC/bispecific/antigen/ORF vector/VLP) and disease/indication/condition/MOA for drug discovery and IVD

It's the GeneMedi's summary page for Target/Biomarker Introduction of INSR. The page also collects GeneMedi's different modalities and formats products for INSR in therapeutics/drug discovery and IVD diagnostics, which is including antibody, ADC, bispecific, antigen, ORF vector, VLP, etc. With GeneMedi's target-insight database-GM ITD database, the INSR target is also connected to human indications/diseases/conditions/MOA.

Target sublocation: Transmembrane Protein.

This gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of insulin or other ligands to this receptor activates the insulin signaling pathway, which regulates glucose uptake and release, as well as the synthesis and storage of carbohydrates, lipids and protein. Mutations in this gene underlie the inherited severe insulin resistance syndromes including type A insulin resistance syndrome, Donohue syndrome and Rabson-Mendenhall syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]

Pre-made INSR-specific INN-index biosimilar (antibody&conjugates)-insulin efsitora alfa, valanafusp alfa, insulin, Valanafusp

Anti-INSR therapeutic INN-index antibodies and conjugates are biosimilars expressed by mammalian cell line as a benchmark reference therapeutic antibody for drug discovery, target MOA research, cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).

Cat No.	Products Name (INN Index)	INN Name	Previous Name	Target	Format	Order
GMP-Bios-INN-870	Pre-Made Insulin Efsitora Alfa Biosimilar, Fusion Protein targeting INSR fused with human IGHG2 Fc (Fragment constant): Recombinant therapeutic protein targeting CD220/HHF5	insulin efsitora alfa		INSR	Fusion Protein
GMP-Bios-INN-1043	Pre-Made Valanafusp Alfa Biosimilar, Fusion Protein targeting INSR fused with human IDUA (iduronidase, alpha-L-) (1:2): Recombinant therapeutic protein targeting CD220/HHF5	valanafusp alfa		INSR	Fusion Protein
GMP-Bios-INN-869	Pre-Made Insulin Biosimilar, Recombinant Protein targeting INSR: Recombinant therapeutic protein targeting CD220/HHF5	insulin		INSR	Recombinant Protein
GMP-Bios-ab-608	Pre-Made Valanafusp biosimilar, Whole mAb Fusion, Anti-INSR Antibody: Anti-CD220/HHF5 therapeutic antibody	Valanafusp		INSR	Whole mAb Fusion

Pre-made anti-INSR inhibitory monoclonal antibody(mab, blocking antibody inhibitor)-benchmark reference antibody for drug discovery and mechanism of action (MOA) research

Pre-made anti-INSR benchmark inhibitory monoclonal antibody(mab, blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). The anti-INSR mab is expressed and produced by mammalian cell line as a benchmark reference therapeutic antibody for biological drug discovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.

Cat No.	Antibody Name	Format	Classified by tag	Order
GM-Tg-hg-T85435-Ab	Anti-INSR monoclonal antibody	mab	Biofunctional antibody, Therapeutics Target antibody