MEK2/MAP2K2: Target/Biomarker Introduction, products summarized (antibody/ADC/bispecific/antigen/ORF vector/VLP) and disease/indication/condition/MOA for drug discovery and IVD
It's the GeneMedi's summary page for Target/Biomarker Introduction of MEK2/MAP2K2. The page also collects GeneMedi's different modalities and formats products for MEK2 in therapeutics/drug discovery and IVD diagnostics, which is including antibody, ADC, bispecific, antigen, ORF vector, VLP, etc. With GeneMedi's target-insight database-GM ITD database, the MEK2 target is also connected to human indications/diseases/conditions/MOA.
Target sublocation: Introcelluar Protein.
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, cognitive disability, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene. [provided by RefSeq, Jul 2008]
Target ID | GM-T89055 |
Target Name | MEK2 |
Gene ID | 5605,26396,58960,721821,611939,101100281,510434,100063190 |
Gene Symbol and Synonyms | CFC4,MAP2K2,MAPKK2,MEK2,MK2,MKK2,PRKMK2 |
Uniprot Accession | P36507,P36506,Q1HG70 |
Uniprot Entry Name | MP2K2_HUMAN,MP2K2_RAT,MP2K2_CANLF |
Protein Sub-location | Introcelluar Protein |
Category | Therapeutics Target |
Disease | Non-Small Cell Lung Cancer |
Gene Ensembl | ENSG00000126934 |
Target Classification | Kinase |
Pre-made anti-MEK2 inhibitory monoclonal antibody(mab, blocking antibody inhibitor)-benchmark antibody for drug discovery and mechanism of action (MOA) research
Pre-made anti-MEK2 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). The anti-MEK2 mab is expressed and produced by mammalian cell line as a benchmark reference therapeutic antibody for biological drug discovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Antibody Name | Species | Format | Classified by tag | Detail |
Anti-MEK2/MAP2K2 monoclonal antibody | Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine | mab | Therapeutics Target antibody | Detail |
Recombinant multi-species MP2K2/ MEK2/ MAP2K2 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis
Genemedi produces Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine MEK2/MAP2K2 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
Products Name | Species | Expression Platform | Detail |
MEK2/MAP2K2 protein | Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine | Mammalian cell | Detail |
Pre-made MAP2K2 viral vector in GM Promise-ORFTM
Cat No. | Products name | NM ID | Species | Type | Detail |
vGMAP000093 | Human MAP2K2 Adenovirus particle | BC018645 | Human | Adenovirus particle | Detail |
vGMLP003890 | human MAP2K2 Lentivirus particle | BC018645 | Human | Lentivirus particle | Detail |
pGMLP003890 | human MAP2K2 Lentivirus plasmid | BC018645 | Human | Lentivirus plasmid | Detail |
vGMAP000521 | Human MAP2K2 Adenovirus particle | BC018645 | Human | Adenovirus particle | Detail |
pGMAP000521 | Human MAP2K2 Adenovirus plasmid | BC018645 | Human | Adenovirus plasmid | Detail |
pGMAP000093 | Human MAP2K2 Adenovirus plasmid | BC018645 | Human | Adenovirus plasmid | Detail |
pGMLPm001697 | mouse Map2k2 Lentivirus plasmid | NM_001347144.1 | Mouse | Lentivirus plasmid | Detail |
pGMLPm001698 | mouse Map2k2 Lentivirus plasmid | NM_023138 | Mouse | Lentivirus plasmid | Detail |
vGMLPm001697 | mouse Map2k2 Lentivirus particle | NM_001347144.1 | Mouse | Lentivirus particle | Detail |
vGMLPm001698 | mouse Map2k2 Lentivirus particle | NM_023138 | Mouse | Lentivirus particle | Detail |
About Promise-ORFTM:
Discover the largest collection of ORF/cDNA expression clones from different species, including human, mouse, rat, and more with GeneMedi's Promise-ORFTM. Our collection of ORFs expression clones come in verified mammalian or viral vectors lentivirus, AAV, and adenovirus) and our Promise-ORFTM viral-ready expression vectors make it easy for you to improve viral vector packaging efficiency or directly transfect mammalian cells, resulting in stronger and easier expression detection. Click to search your GOI
If you want to obtain higher quantities of plasmids (mg), please visit GM TransExcellent Plasmid DNA Rapid Preparation Service.