Advanced Therapy, Cell Therapy and Gene Therapy News
Aug. 29, 2019 | 8:47 amThe obesity epidemic affects nearly half a billion people worldwide, many of them children. Obesity-related diseases including heart disease, stroke, type 2 diabetes, and cancer are a leading cause ...
Cancer gene therapy:Dual-vector prodrug activator gene therapy displays synergistic cytocidal effects on cancer
Sep 9, 2019 | 9:29 amRetroviral replicating vectors (RRVs) has been proved as an excellent gene therapy vector to achieve efficient gene transduction. To date, more than 499 clinical trials have been carried out using lentivirus vectors for gene delivery and promising gene therapy outcomes have been achieved in a variety of diseases, mostly in cancer. Today, a dual-vector prodrug activator gene therapy has been designed by one research team at the University of Miami to use two different RRVs carrying different prodrug activator genes, which displays synergistic cytocidal effects on different cancer models and indicates the potential utility of dual-vector gene therapy in the future.
Sep 9, 2019 | 9:29 amRecombinant adeno-associated virus (AAV) vectors exhibit promising outcomes on gene therapy with its durable expression in the targeting tissues. Even so, in most cases, AAV immunogenicity still represents a major limitation for its clinical trials. Recently, a research team from Sorbonne Université and INSERM U974 (France) has employed an effective means to avoid AAV immunogenicity, which makes AAV safer and provide reference for its further clinical trial.
July 31, 2019 | 9:29 amResearchers have used CRISPR-Cas9 to edit long-lived blood stem cells to reverse the clinical symptoms observed with several ...
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