Drug Discovery News

The great escape: tumour cell plasticity in resistance to targeted therapy

Review Article | 10 October 2019

The success of targeted therapies in cancer treatment has been impeded by various mechanisms of resistance. Besides the acquisition of resistance-conferring genetic mutations...

Targeting mRNA processing as an anticancer strategy

Review Article | 25 September 2019

Discoveries in the past decade have highlighted the potential of mRNA as a therapeutic target for cancer. Specifically, RNA sequencing revealed that, in addition...

Pharmacological modulation of nucleic acid sensors — therapeutic potential and persisting obstacles

Review Article | 25 September 2019

Nucleic acid sensors, primarily TLR and RLR family members, as well as cGAS–STING signalling, play a critical role in the preservation of cellular and organismal homeostasis. Accordingly, deregulated...

Targeting metabolic dysregulation for fibrosis therapy

Review Article | 23 September 2019

Fibrosis is the abnormal deposition of extracellular matrix, which can lead to organ dysfunction, morbidity, and death. The disease burden caused by fibrosis is...

Genetic behavioral screen identifies an orphan anti-opioid system

Review Article | 20 September 2019

Opioids target the μ-opioid receptor (MOR) to produce unrivaled pain management, but their addictive properties can lead to severe abuse. We developed a whole-animal...

Design of stapled antimicrobial peptides that are stable, nontoxic and kill antibiotic-resistant bacteria in mice

Review Article | 19 September 2019

The clinical translation of cationic α-helical antimicrobial peptides (AMPs) has been hindered by structural instability, proteolytic degradation and in vivo toxicity...

ADCK3/COQ8A: the choice target of the UbiB protein kinase-like family

Biobusiness Briefs | 16 September 2019

UbiB kinase-like proteins exist in archaea, bacteria and eukaryotes, and comprise ~25% of all microbial protein kinase-like (PKL) enzymes. The founding member of the UbiB family, UbiB from Escherichia...

Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials

Review Article | 11 September 2019

Ninety-seven percent of drug-indication pairs that are tested in clinical trials in oncology never advance to receive U.S. Food and Drug Administration approval. While...

Targeting cardiac fibrosis with engineered T cells

Review Article | 11 September 2019

Fibrosis is observed in nearly every form of myocardial disease1. Upon injury, cardiac fibroblasts in the heart begin to remodel the myocardium by depositing...

Validation of the protein kinase PfCLK3 as a multistage cross-species malarial drug target

Review Article | 30 August 2019

The requirement for next-generation antimalarials to be both curative and transmission-blocking necessitates the identification of previously undiscovered druggable...

CD24 signalling through macrophage Siglec-10 is a target for cancer immunotherapy

Review Article | 31 July 2019

Ovarian cancer and triple-negative breast cancer are among the most lethal diseases affecting women, with few targeted therapies and high rates of metastasis. Cancer cells are capable of evading clearance by macrophages through the overexpression of anti-phagocytic surface proteins ...

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