Human NPPB/BNP ORF/cDNA clone-Adeno-associate virus(AAV) plasmid (NM_002521.2)

Cat. No.: pGMAAV000027
Size: 10 µg
Concentration: generally 0.5ug/ul, usually not less than 0.3ug/ul
Leading Time: 3-7 working days

Pre-made Human NPPB/BNP Adeno-associated virus expression plasmid (ITR-vector) for NPPB AAV packaging, NPPB AAV production.The purified Human NPPB/BNP AAV particle serves as an invaluable asset for in-depth in vivo NPPB studies, mechanism of action (MOA) research, and the evolution of NPPB-associated gene therapy strategies.

Our GM-AAV ITR vector is optimized with the G-NEXT™ multi-serotypes AAV vector system. Explore the G-NEXT™ system in detail.

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Product Description

Catalog ID pGMAAV000027
Gene Name NPPB
Accession Number NM_002521.2
Gene ID 4879
Species Human
Product Type Adeno-associate virus(AAV) plasmid (overexpression)
Insert Length 405 bp
Gene Alias BNP
Fluorescent Reporter GFP
Mammalian Cell Selection Null
Fusion Tag Null
Promoter CMV
Resistance Amplicin
ORF Nucleotide Sequence ATGGATCCCCAGACAGCACCTTCCCGGGCGCTCCTGCTCCTGCTCTTCTTGCATCTGGCTTTCCTGGGAGGTCGTTCCCACCCGCTGGGCAGCCCCGGTTCAGCCTCGGACTTGGAAACGTCCGGGTTACAGGAGCAGCGCAACCATTTGCAGGGCAAACTGTCGGAGCTGCAGGTGGAGCAGACATCCCTGGAGCCCCTCCAGGAGAGCCCCCGTCCCACAGGTGTCTGGAAGTCCCGGGAGGTAGCCACCGAGGGCATCCGTGGGCACCGCAAAATGGTCCTCTACACCCTGCGGGCACCACGAAGCCCCAAGATGGTGCAAGGGTCTGGCTGCTTTGGGAGGAAGATGGACCGGATCAGCTCCTCCAGTGGCCTGGGCTGCAAAGTGCTGAGGCGGCATTAA
ORF Protein Sequence MDPQTAPSRALLLLLFLHLAFLGGRSHPLGSPGSASDLETSGLQEQRNHLQGKLSELQVEQTSLEPLQESPRPTGVWKSREVATEGIRGHRKMVLYTLRAPRSPKMVQGSGCFGRKMDRISSSSGLGCKVLRRH

Reference




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    Associated products


    Category Cat No. Products Name
    Target Antibody GM-Tg-g-T55302-Ab Anti-ANFB/ BNP/ NPPB functional antibody
    Target Antigen GM-Tg-g-T55302-Ag BNP/NPPB protein
    ORF Viral Vector pGMAAV000027 Human NPPB Adeno-associate virus(AAV) plasmid
    ORF Viral Vector vGMAAV000027 Human NPPB Adeno-associate virus(AAV) particle


    Target information

    Target ID GM-T55302
    Target Name BNP
    Gene ID 4879, 18158, 715053, 25105, 493764, 487441, 508734, 100056123
    Gene Symbol and Synonyms BNF,BNP,Iso-ANP,NNX,NPPB
    Uniprot Accession P16860
    Uniprot Entry Name ANFB_HUMAN
    Protein Sub-location Secreted Protein/Potential Cytokines
    Category Therapeutics Target, Diagnostics Biomarker
    Disease Not Available
    Gene Ensembl ENSG00000120937
    Target Classification Not Available

    This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. The presence of myocardial injury is a significant predictor of mortality in hospitalized coronavirus disease 2019 (COVID-19) patients, and there is evidence of increased levels of natriuretic peptide B in hospitalized non-survivor COVID-19 patients. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Mutations in this gene have been associated with postmenopausal osteoporosis. [provided by RefSeq, Aug 2020]



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