Anti-ANFB/ BNP/ NPPB functional antibody

Anti-ANFB/ BNP/ NPPB functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to BNP/NPPB products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T55302-Ab-1/ GM-Tg-hg-T55302-Ab-2Anti-Human BNP/NPPB monoclonal antibodyHuman
GM-Tg-rg-T55302-Ab-1/ GM-Tg-rg-T55302-Ab-2Anti-Rat BNP/NPPB monoclonal antibodyRat
GM-Tg-mg-T55302-Ab-1/ GM-Tg-mg-T55302-Ab-2Anti-Mouse BNP/NPPB monoclonal antibodyMouse
GM-Tg-cynog-T55302-Ab-1/ GM-Tg-cynog-T55302-Ab-2Anti-Cynomolgus/ Rhesus macaque BNP/NPPB monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T55302-Ab-1/ GM-Tg-felg-T55302-Ab-2Anti-Feline BNP/NPPB monoclonal antibodyFeline
GM-Tg-cang-T55302-Ab-1/ GM-Tg-cang-T55302-Ab-2Anti-Canine BNP/NPPB monoclonal antibodyCanine
GM-Tg-bovg-T55302-Ab-1/ GM-Tg-bovg-T55302-Ab-2Anti-Bovine BNP/NPPB monoclonal antibodyBovine
GM-Tg-equg-T55302-Ab-1/ GM-Tg-equg-T55302-Ab-2Anti-Equine BNP/NPPB monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T55302-Ab-1/ GM-Tg-hg-T55302-Ab-2; GM-Tg-rg-T55302-Ab-1/ GM-Tg-rg-T55302-Ab-2;
GM-Tg-mg-T55302-Ab-1/ GM-Tg-mg-T55302-Ab-2; GM-Tg-cynog-T55302-Ab-1/ GM-Tg-cynog-T55302-Ab-2;
GM-Tg-felg-T55302-Ab-1/ GM-Tg-felg-T55302-Ab-2; GM-Tg-cang-T55302-Ab-1/ GM-Tg-cang-T55302-Ab-2;
GM-Tg-bovg-T55302-Ab-1/ GM-Tg-bovg-T55302-Ab-2; GM-Tg-equg-T55302-Ab-1/ GM-Tg-equg-T55302-Ab-2
Products NameAnti-BNP/NPPB monoclonal antibody
Formatmab
Target NameBNP
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-BNP benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-T55302-Ag-1Recombinant multi-species ANFB/ BNP/ NPPB protein
    ORF Viral VectorvGMAAV000027human NPPB AAV particle
    ORF Viral VectorpGMAAV000027human NPPB AAV plasmid
    ORF Viral VectorpGMLPm000014mouse Nppb Lentivirus plasmid
    ORF Viral VectorvGMLPm000014mouse Nppb Lentivirus particle


    Target information

    Target IDGM-T55302
    Target NameBNP
    Gene ID4879,18158,25105,715053,487441,493764,508734,100056123
    Gene Symbol and SynonymsBNF,BNP,Iso-ANP,NNX,NPPB
    Uniprot AccessionP16860,P13205,P16859,P13204
    Uniprot Entry NameANFB_HUMAN,ANFB_RAT,ANFB_CANLF,ANFB_BOVIN
    Protein Sub-locationSecreted Protein/Potential Cytokines
    CategoryTherapeutics Target, Diagnostics Biomarker
    DiseaseN/A
    Gene EnsemblENSG00000120937
    Target ClassificationN/A

    The target: BNP, gene name: NPPB, also named as BNP. This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. The presence of myocardial injury is a significant predictor of mortality in hospitalized coronavirus disease 2019 (COVID-19) patients, and there is evidence of increased levels of natriuretic peptide B in hospitalized non-survivor COVID-19 patients. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Mutations in this gene have been associated with postmenopausal osteoporosis. [provided by RefSeq, Aug 2020].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.