Human CBL/C-CBL/ CBL2 ORF/cDNA clone-Adenovirus plasmid (NM_005188.3)

Pre-made Human CBL/C-CBL/ CBL2 adenoviral expression plasmid for CBL adenovirus packaging, CBL adenovirus.

Our GM-Adenovirus vector is optimized with the GMVC-modified Adeasy adenovirus packaging system. Find more about the GMVC-modified adenovirus packaging system.

Target products collectionGo to CBL/C-CBL products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)



Product information

Catalog No. Product Name Plasmid Grade Plasmid quantity
pGMAD000179 Human CBL Adenovirus plasmid Research Grade 10mg, 50mg, 100mg, 500mg, >1g
GMP-like Grade 10mg, 50mg, 100mg, 500mg, >1g
High Quality (HQ) Grade
Seed 5ug


Product Description

Catalog ID pGMAD000179
Gene Name CBL
Accession Number NM_005188.3
Gene ID 867
Species Human
Product Type Adenovirus plasmid (overexpression)
Insert Length 2721 bp
Gene Alias C-CBL, CBL2, FRA11B, NSLL, RNF55
Fluorescent Reporter
Mammalian Cell Selection Null
Fusion Tag 3xflag (C-Terminal)
Promoter CMV
Resistance Amplicin

Reference




    Data / case study


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    Associated products


    Category Cat No. Products Name
    Target Antibody GM-Tg-g-T25309-Ab Anti-CBL monoclonal antibody
    Target Antigen GM-Tg-g-T25309-Ag CBL protein
    ORF Viral Vector pGMLV001373 Human CBL Lentivirus plasmid
    ORF Viral Vector pGMAD000179 Human CBL Adenovirus plasmid
    ORF Viral Vector pGMPC001228 Human CBL Mammalian (Non-Viral Vector) plasmid
    ORF Viral Vector vGMLV001373 Human CBL Lentivirus particle
    ORF Viral Vector vGMAD000179 Human CBL Adenovirus particle


    Target information

    Target ID GM-T25309
    Target Name CBL
    Gene ID 867, 12402, 704311, 500985, 101096508, 489369, 527418, 100071403
    Gene Symbol and Synonyms 4732447J05Rik,C-CBL,c-cbl-like,CBL,Cbl-2,CBL2,FRA11B,NSLL,RGD1561386,RNF55
    Uniprot Accession P22681
    Uniprot Entry Name CBL_HUMAN
    Protein Sub-location Introcelluar Protein
    Category Therapeutics Target, Diagnostics Biomarker
    Disease Cancer
    Gene Ensembl ENSG00000110395
    Target Classification Tumor-associated antigen (TAA)

    This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia, and expansion of CGG repeats in the 5' UTR has been associated with Jacobsen syndrome. Mutations in this gene are also the cause of Noonan syndrome-like disorder. [provided by RefSeq, Jul 2016]



    About GMVC

    GDU



    GMVC (GM Vector Core) is GeneMedi’s unique platform for QbD Viral vectors Processes development and manufacturing. In GMVC, our core expertise lies in the tailored production of viral vectors, including adeno-associated virus (AAV), lentivirus, and adenovirus. Our state-of-the-art facilities are equipped for scalable manufacturing, ensuring high-quality viral vector production to meet both research and therapeutic needs. Our expert team specializes in process development, leveraging innovative technology and extensive industry knowledge to provide clients with tailored solutions that exceed expectations. GMVC will be the ideal partner for scientists and healthcare professionals seeking reliable and efficient viral vector production services.