Human CBL/C-CBL/ CBL2 ORF/cDNA clone-Adenovirus plasmid (NM_005188.3)
Pre-made Human CBL/C-CBL/ CBL2 adenoviral expression plasmid for CBL adenovirus packaging, CBL adenovirus.
Our GM-Adenovirus vector is optimized with the GMVC-modified Adeasy adenovirus packaging system. Find more about the GMVC-modified adenovirus packaging system.
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Product information
Catalog No. | Product Name | Plasmid Grade | Plasmid quantity |
---|---|---|---|
pGMAD000179 | Human CBL Adenovirus plasmid | Research Grade | 10mg, 50mg, 100mg, 500mg, >1g |
GMP-like Grade | 10mg, 50mg, 100mg, 500mg, >1g | ||
High Quality (HQ) Grade | |||
Seed | 5ug |
Product Description
Catalog ID | pGMAD000179 |
Gene Name | CBL |
Accession Number | NM_005188.3 |
Gene ID | 867 |
Species | Human |
Product Type | Adenovirus plasmid (overexpression) |
Insert Length | 2721 bp |
Gene Alias | C-CBL, CBL2, FRA11B, NSLL, RNF55 |
Fluorescent Reporter | |
Mammalian Cell Selection | Null |
Fusion Tag | 3xflag (C-Terminal) |
Promoter | CMV |
Resistance | Amplicin |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Category | Cat No. | Products Name |
---|---|---|
Target Antibody | GM-Tg-g-T25309-Ab | Anti-CBL monoclonal antibody |
Target Antigen | GM-Tg-g-T25309-Ag | CBL protein |
ORF Viral Vector | pGMLV001373 | Human CBL Lentivirus plasmid |
ORF Viral Vector | pGMAD000179 | Human CBL Adenovirus plasmid |
ORF Viral Vector | pGMPC001228 | Human CBL Mammalian (Non-Viral Vector) plasmid |
ORF Viral Vector | vGMLV001373 | Human CBL Lentivirus particle |
ORF Viral Vector | vGMAD000179 | Human CBL Adenovirus particle |
Target information
Target ID | GM-T25309 |
Target Name | CBL |
Gene ID | 867, 12402, 704311, 500985, 101096508, 489369, 527418, 100071403 |
Gene Symbol and Synonyms | 4732447J05Rik,C-CBL,c-cbl-like,CBL,Cbl-2,CBL2,FRA11B,NSLL,RGD1561386,RNF55 |
Uniprot Accession | P22681 |
Uniprot Entry Name | CBL_HUMAN |
Protein Sub-location | Introcelluar Protein |
Category | Therapeutics Target, Diagnostics Biomarker |
Disease | Cancer |
Gene Ensembl | ENSG00000110395 |
Target Classification | Tumor-associated antigen (TAA) |
This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia, and expansion of CGG repeats in the 5' UTR has been associated with Jacobsen syndrome. Mutations in this gene are also the cause of Noonan syndrome-like disorder. [provided by RefSeq, Jul 2016]
About GMVC
GMVC (GM Vector Core) is GeneMedi’s unique platform for QbD Viral vectors Processes development and manufacturing. In GMVC, our core expertise lies in the tailored production of viral vectors, including adeno-associated virus (AAV), lentivirus, and adenovirus. Our state-of-the-art facilities are equipped for scalable manufacturing, ensuring high-quality viral vector production to meet both research and therapeutic needs. Our expert team specializes in process development, leveraging innovative technology and extensive industry knowledge to provide clients with tailored solutions that exceed expectations. GMVC will be the ideal partner for scientists and healthcare professionals seeking reliable and efficient viral vector production services.