Recombinant multi-species CBL/ C-CBL2/ FRA11B protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine CBL protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

The target: CBL, gene name: CBL, also named as C-CBL2, FRA11B, NSLL, RNF55, CBL. This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia, and expansion of CGG repeats in the 5' UTR has been associated with Jacobsen syndrome. Mutations in this gene are also the cause of Noonan syndrome-like disorder. [provided by RefSeq, Jul 2016].

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Catalog No.	Product Name	Species	Size	Price
GM-Tg-hg-T25309-Ag-1	Human CBL protein	Human	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-rg-T25309-Ag-1	Rat CBL protein	Rat	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-mg-T25309-Ag-1	Mouse CBL protein	Mouse	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-cynog-T25309-Ag-1	Cynomolgus/ Rhesus macaque CBL protein	Cynomolgus/ Rhesus macaque	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-felg-T25309-Ag-1	Feline CBL protein	Feline	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-cang-T25309-Ag-1	Canine CBL protein	Canine	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-bovg-T25309-Ag-1	Bovine CBL protein	Bovine	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-bovg-T25309-Ag-1	Equine CBL protein	Equine	1mg/10mg/100mg/≥100mg	Inquiry
Shipping Cost:				760.00

Description

Catalog No.	GM-Tg-hg-T25309-Ag, GM-Tg-rg-T25309-Ag, GM-Tg-mg-T25309-Ag, GM-Tg-cynog-T25309-Ag, GM-Tg-felg-T25309-Ag, GM-Tg-cang-T25309-Ag, GM-Tg-bovg-T25309-Ag, GM-Tg-equg-T25309-Ag-1
Products Name	CBL protein
Species	Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name	CBL
Protein Sub-location	Introcelluar Protein
Isotypes	Recombinant protein
Expression platform	Mammalian cell
Bioactivity validation	Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag	His
Products description	Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine CBL protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity	Purity: ≥95% (SDS-PAGE)
Application	In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation	Supplied as a 0.2 μM filtered solution of PBS, PH7.4.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.