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Anti-CBL monoclonal antibody
Pre-made anti-CBL monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to CBL/CBL products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T25309-Ab-1/ GM-Tg-hg-T25309-Ab-2 | Anti-Human CBL monoclonal antibody | Human |
| GM-Tg-rg-T25309-Ab-1/ GM-Tg-rg-T25309-Ab-2 | Anti-Rat CBL monoclonal antibody | Rat |
| GM-Tg-mg-T25309-Ab-1/ GM-Tg-mg-T25309-Ab-2 | Anti-Mouse CBL monoclonal antibody | Mouse |
| GM-Tg-cynog-T25309-Ab-1/ GM-Tg-cynog-T25309-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CBL monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T25309-Ab-1/ GM-Tg-felg-T25309-Ab-2 | Anti-Feline CBL monoclonal antibody | Feline |
| GM-Tg-cang-T25309-Ab-1/ GM-Tg-cang-T25309-Ab-2 | Anti-Canine CBL monoclonal antibody | Canine |
| GM-Tg-bovg-T25309-Ab-1/ GM-Tg-bovg-T25309-Ab-2 | Anti-Bovine CBL monoclonal antibody | Bovine |
| GM-Tg-equg-T25309-Ab-1/ GM-Tg-equg-T25309-Ab-2 | Anti-Equine CBL monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T25309-Ab-1/ GM-Tg-hg-T25309-Ab-2; GM-Tg-rg-T25309-Ab-1/ GM-Tg-rg-T25309-Ab-2; GM-Tg-mg-T25309-Ab-1/ GM-Tg-mg-T25309-Ab-2; GM-Tg-cynog-T25309-Ab-1/ GM-Tg-cynog-T25309-Ab-2; GM-Tg-felg-T25309-Ab-1/ GM-Tg-felg-T25309-Ab-2; GM-Tg-cang-T25309-Ab-1/ GM-Tg-cang-T25309-Ab-2; GM-Tg-bovg-T25309-Ab-1/ GM-Tg-bovg-T25309-Ab-2; GM-Tg-equg-T25309-Ab-1/ GM-Tg-equg-T25309-Ab-2 |
| Products Name | Anti-CBL monoclonal antibody |
| Format | mab |
| Target Name | CBL |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody, Diagnostic target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-CBL monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T25309-Ag-1 | Recombinant multi-species CBL/ C-CBL2/ FRA11B protein |
| ORF Viral Vector | pGMAD000179 | human CBL Adenovirus plasmid |
| ORF Viral Vector | vGMAD000179 | human CBL Adenovirus particle |
Target information
| Target ID | GM-T25309 |
| Target Name | CBL |
| Gene ID | 867,12402,500985,704311,489369,101096508,527418,100071403 |
| Gene Symbol and Synonyms | 4732447J05Rik,C-CBL,c-cbl-like,CBL,Cbl-2,CBL2,FRA11B,NSLL,RGD1561386,RNF55 |
| Uniprot Accession | P22681 |
| Uniprot Entry Name | CBL_HUMAN |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target, Diagnostics Biomarker |
| Disease | Cancer |
| Gene Ensembl | ENSG00000110395 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: CBL, gene name: CBL, also named as C-CBL2, FRA11B, NSLL, RNF55, CBL. This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia, and expansion of CGG repeats in the 5' UTR has been associated with Jacobsen syndrome. Mutations in this gene are also the cause of Noonan syndrome-like disorder. [provided by RefSeq, Jul 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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