Human SSH1/SSH1L ORF/cDNA clone-Lentivirus plasmid (NM_018984)

Cat. No.: pGMLP001740
Size: 10 µg
Concentration: generally 0.5ug/ul, usually not less than 0.3ug/ul
Leading Time: 3-7 working days

Pre-made Human SSH1/SSH1L Lentiviral expression plasmid for SSH1 lentivirus packaging, SSH1 lentivirus production, overexpression stable cell line development, cell transient transfection and gene delivery targeting T/B/NK cells, macrophages, cardiomyocytes, hepatocytes, and neurons.

Our GM-Lentiviral vector is seamlessly integrated with the GM lentivirus packaging system. Discover more about the GM lentivirus packaging system.

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Product Description

Catalog ID pGMLP001740
Gene Name SSH1
Accession Number NM_018984
Gene ID 54434
Species Human
Product Type Lentivirus plasmid (overexpression)
Insert Length 3150 bp
Gene Alias SSH1L
Fluorescent Reporter ZsGreen
Mammalian Cell Selection Puromyocin
Fusion Tag 3xflag (C-Terminal)
Promoter CMV
Resistance Amplicin
ORF Nucleotide Sequence ATGGCCCTGGTGACCCTGCAGCGCTCGCCCACGCCCAGCGCCGCCTCCTCCTCGGCCAGCAACAGCGAGTTGGAGGCTGGCAGCGAAGAAGATCGAAAATTAAACCTCAGCTTAAGTGAGAGCTTTTTCATGGTGAAAGGCGCAGCCCTCTTCTTACAACAGGGAAGCAGCCCTCAAGGCCAGCGGAGTCTTCAGCACCCCCACAAGCATGCAGGTGATCTGCCTCAACATCTTCAGGTGATGATCAACCTTCTGCGTTGCGAAGACAGAATCAAGCTGGCAGTGCGCCTGGAGAGCGCCTGGGCGGACCGGGTCCGGTACATGGTGGTGGTGTACAGCAGCGGGCGCCAGGACACCGAGGAGAATATCTTGCTGGGAGTGGACTTTTCCAGTAAGGAAAGTAAAAGCTGCACCATTGGGATGGTTCTCCGACTGTGGAGCGACACGAAAATCCACCTTGATGGAGATGGTGGGTTCAGCGTGAGCACAGCAGGAAGGATGCACATATTTAAGCCTGTGTCTGTCCAGGCCATGTGGTCTGCCCTGCAGGTGCTTCACAAGGCCTGCGAAGTGGCCCGGAGGCACAACTACTTCCCCGGGGGTGTAGCTCTCATCTGGGCTACCTACTATGAGAGCTGCATCAGCTCCGAGCAGAGCTGCATCAACGAGTGGAACGCCATGCAGGACCTGGAGTCTACGCGGCCCGACTCCCCCGCGCTATTTGTGGACAAGCCCACTGAAGGGGAAAGGACCGAGCGCCTCATCAAAGCCAAGCTCCGAAGCATCATGATGAGCCAGGATCTAGAAAATGTGACTTCCAAAGAGATTCGTAATGAATTAGAGAAACAGATGAATTGTAACTTGAAGGAACTCAAGGAATTTATAGACAATGAGATGCTACTTATCTTGGGACAGATGGACAAGCCCTCCCTTATCTTCGATCATCTTTATCTCGGCTCTGAATGGAATGCATCCAATCTGGAGGAACTGCAGGGCTCAGGGGTTGATTACATTTTAAATGTTACCAGAGAAATCGATAATTTTTTTCCTGGCTTATTTGCATATCATAACATCCGAGTCTACGATGAAGAGACCACAGACCTCCTCGCCCACTGGAATGAAGCGTATCATTTTATAAACAAAGCGAAGAGGAACCATTCCAAGTGCCTGGTGCATTGCAAAATGGGCGTGAGTCGCTCGGCCTCCACAGTCATAGCCTATGCAATGAAGGAATTCGGCTGGCCTCTGGAAAAAGCATATAACTATGTAAAGCAGAAGCGCAGCATCACGCGCCCCAACGCGGGCTTTATGAGGCAGCTGTCTGAGTATGAAGGCATCTTGGATGCAAGCAAACAGCGGCACAACAAGCTGTGGCGTCAGCAGACAGACAGCAGCCTCCAGCAGCCTGTGGATGACCCTGCAGGACCTGGCGACTTCTTGCCAGAGACCCCAGATGGCACCCCGGAAAGCCAGCTGCCCTTCTTGGATGATGCCGCCCAGCCCGGCTTAGGGCCCCCCCTCCCCTGCTGTTTCCGGCGACTCTCAGACCCCCTTCTGCCTTCCCCTGAGGATGAAACTGGCAGCTTGGTCCACCTGGAGGATCCGGAGAGGGAGGCTCTGTTGGAGGAAGCTGCTCCACCTGCAGAGGTGCACAGGCCGGCCAGACAGCCCCAGCAAGGTTCCGGACTCTGTGAGAAGGATGTGAAGAAGAAACTAGAGTTTGGGAGTCCCAAAGGTCGGAGCGGCTCCTTGCTGCAGGTGGAGGAGACGGAAAGGGAGGAGGGCCTGGGAGCAGGGAGGTGGGGGCAGCTTCCAACCCAGCTCGATCAAAACCTGCTCAACTCGGAGAACCTAAACAACAACAGCAAGAGGAGCTGTCCCAACGGCATGGAGGATGATGCTATATTTGGGATCCTTAACAAAGTGAAGCCTTCCTATAAATCCTGTGCCGACTGCATGTACCCTACAGCCAGCGGGGCTCCTGAGGCCTCCAGGGAGCGATGTGAGGACCCCAATGCTCCCGCCATCTGCACCCAGCCAGCCTTCCTACCCCACATCACGTCCTCCCCTGTGGCCCACTTGGCCAGCAGGTCCCGTGTTCCGGAGAAGCCAGCCTCTGGCCCAACCGAACCTCCCCCGTTCCTACCACCAGCAGGCTCCAGGAGGGCAGACACCAGTGGCCCTGGGGCTGGAGCTGCCCTAGAGCCACCAGCCAGCCTTTTGGAACCTTCCAGAGAGACCCCAAAAGTCCTGCCAAAGTCCCTCCTTTTGAAGAATTCTCACTGTGATAAGAACCCTCCCAGCACAGAAGTGGTAATAAAGGAAGAATCGTCACCCAAGAAAGATATGAAGCCAGCCAAGGACCTGAGGCTTCTGTTCAGTAATGAATCTGAGAAGCCGACAACCAACAGCTACCTGATGCAGCACCAGGAGTCCATCATTCAGCTGCAGAAGGCAGGCTTGGTCCGCAAGCACACCAAAGAGCTAGAGCGGCTGAAGAGCGTGCCTGCAGACCCAGCACCTCCCTCCAGGGATGGCCCTGCCAGCAGGCTGGAGGCCAGCATCCCCGAGGAGAGCCAGGATCCAGCCGCGCTCCACGAGCTGGGCCCCCTGGTTATGCCCAGCCAGGCCGGGAGTGATGAGAAGTCAGAGGCCGCCCCCGCTTCATTGGAAGGAGGCTCACTGAAGAGCCCCCCTCCTTTCTTCTACCGCCTGGACCACACCAGTAGTTTCTCAAAAGACTTTCTGAAGACCATCTGCTACACCCCCACCTCCTCTTCCATGAGCTCCAACCTGACCCGGAGCTCCAGCAGCGATAGCATCCACAGTGTCCGTGGGAAGCCCGGGCTGGTGAAGCAGCGGACACAGGAGATTGAGACCCGGCTCCGGCTGGCGGGCCTCACCGTCTCTTCCCCACTGAAGCGCTCACACTCTCTTGCCAAGCTGGGGAGTCTCACCTTCTCAACGGAAGACCTGTCCAGTGAGGCTGACCCGTCCACCGTCGCTGACTCCCAGGACACCACTTTGAGTGAATCTTCCTTCTTGCATGAGCCCCAGGGAACCCCGAGGGACCCAGCTGCAACCTCCAAACCATCAGGGAAACCCGCCCCAGAAAACTTAAAGAGCCCTTCGTGGATGAGCAAAAGCTGA
ORF Protein Sequence MALVTLQRSPTPSAASSSASNSELEAGSEEDRKLNLSLSESFFMVKGAALFLQQGSSPQGQRSLQHPHKHAGDLPQHLQVMINLLRCEDRIKLAVRLESAWADRVRYMVVVYSSGRQDTEENILLGVDFSSKESKSCTIGMVLRLWSDTKIHLDGDGGFSVSTAGRMHIFKPVSVQAMWSALQVLHKACEVARRHNYFPGGVALIWATYYESCISSEQSCINEWNAMQDLESTRPDSPALFVDKPTEGERTERLIKAKLRSIMMSQDLENVTSKEIRNELEKQMNCNLKELKEFIDNEMLLILGQMDKPSLIFDHLYLGSEWNASNLEELQGSGVDYILNVTREIDNFFPGLFAYHNIRVYDEETTDLLAHWNEAYHFINKAKRNHSKCLVHCKMGVSRSASTVIAYAMKEFGWPLEKAYNYVKQKRSITRPNAGFMRQLSEYEGILDASKQRHNKLWRQQTDSSLQQPVDDPAGPGDFLPETPDGTPESQLPFLDDAAQPGLGPPLPCCFRRLSDPLLPSPEDETGSLVHLEDPEREALLEEAAPPAEVHRPARQPQQGSGLCEKDVKKKLEFGSPKGRSGSLLQVEETEREEGLGAGRWGQLPTQLDQNLLNSENLNNNSKRSCPNGMEDDAIFGILNKVKPSYKSCADCMYPTASGAPEASRERCEDPNAPAICTQPAFLPHITSSPVAHLASRSRVPEKPASGPTEPPPFLPPAGSRRADTSGPGAGAALEPPASLLEPSRETPKVLPKSLLLKNSHCDKNPPSTEVVIKEESSPKKDMKPAKDLRLLFSNESEKPTTNSYLMQHQESIIQLQKAGLVRKHTKELERLKSVPADPAPPSRDGPASRLEASIPEESQDPAALHELGPLVMPSQAGSDEKSEAAPASLEGGSLKSPPPFFYRLDHTSSFSKDFLKTICYTPTSSSMSSNLTRSSSSDSIHSVRGKPGLVKQRTQEIETRLRLAGLTVSSPLKRSHSLAKLGSLTFSTEDLSSEADPSTVADSQDTTLSESSFLHEPQGTPRDPAATSKPSGKPAPENLKSPSWMSKS

Reference




    Data / case study


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    Associated products


    Category Cat No. Products Name
    Target Antibody GM-Tg-g-MP2337-Ab Anti-SSH1/ SSH1L monoclonal antibody
    Target Antigen GM-Tg-g-MP2337-Ag SSH1 VLP (virus-like particle)
    ORF Viral Vector pGMLP001740 Human SSH1 Lentivirus plasmid
    ORF Viral Vector vGMLP001740 Human SSH1 Lentivirus particle


    Target information

    Target ID GM-MP2337
    Target Name SSH1
    Gene ID 54434, 231637, 707809, 304580, 101094543, 477526, 538233
    Gene Symbol and Synonyms Gm1394,Gm1395,SSH-1,SSH-1L,SSH1,SSH1L
    Uniprot Accession Q8WYL5
    Uniprot Entry Name SSH1_HUMAN
    Protein Sub-location Transmembrane Protein
    Category Not Available
    Disease Not Available
    Gene Ensembl ENSG00000084112
    Target Classification Not Available

    The protein encoded by this gene belongs to the slingshot homolog (SSH) family of phosphatases, which regulate actin filament dynamics. The SSH proteins dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Cofilin is inactivated by kinases such as LIM domain kinase-1 (LIMK1), which may also be dephosphorylated and inactivated by SSH proteins. The SSH family thus appears to play a role in actin dynamics by reactivating cofilin proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]



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