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Anti-SSH1/ SSH1L monoclonal antibody
Anti-SSH1/ SSH1L antibody for FACS & in-vivo assay
Go to SSH1/SSH1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP2337-Ab-1/ GM-Tg-hg-MP2337-Ab-2 | Anti-Human SSH1 monoclonal antibody | Human |
| GM-Tg-rg-MP2337-Ab-1/ GM-Tg-rg-MP2337-Ab-2 | Anti-Rat SSH1 monoclonal antibody | Rat |
| GM-Tg-mg-MP2337-Ab-1/ GM-Tg-mg-MP2337-Ab-2 | Anti-Mouse SSH1 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP2337-Ab-1/ GM-Tg-cynog-MP2337-Ab-2 | Anti-Cynomolgus/ Rhesus macaque SSH1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP2337-Ab-1/ GM-Tg-felg-MP2337-Ab-2 | Anti-Feline SSH1 monoclonal antibody | Feline |
| GM-Tg-cang-MP2337-Ab-1/ GM-Tg-cang-MP2337-Ab-2 | Anti-Canine SSH1 monoclonal antibody | Canine |
| GM-Tg-bovg-MP2337-Ab-1/ GM-Tg-bovg-MP2337-Ab-2 | Anti-Bovine SSH1 monoclonal antibody | Bovine |
| GM-Tg-equg-MP2337-Ab-1/ GM-Tg-equg-MP2337-Ab-2 | Anti-Equine SSH1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP2337-Ab-1/ GM-Tg-hg-MP2337-Ab-2; GM-Tg-rg-MP2337-Ab-1/ GM-Tg-rg-MP2337-Ab-2; GM-Tg-mg-MP2337-Ab-1/ GM-Tg-mg-MP2337-Ab-2; GM-Tg-cynog-MP2337-Ab-1/ GM-Tg-cynog-MP2337-Ab-2; GM-Tg-felg-MP2337-Ab-1/ GM-Tg-felg-MP2337-Ab-2; GM-Tg-cang-MP2337-Ab-1/ GM-Tg-cang-MP2337-Ab-2; GM-Tg-bovg-MP2337-Ab-1/ GM-Tg-bovg-MP2337-Ab-2; GM-Tg-equg-MP2337-Ab-1/ GM-Tg-equg-MP2337-Ab-2 |
| Products Name | Anti-SSH1 monoclonal antibody |
| Format | mab |
| Target Name | SSH1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-SSH1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species SSH1/ SSH1L VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMLP001740 | human SSH1 Lentivirus particle |
| ORF Viral Vector | pGMLP001740 | human SSH1 Lentivirus plasmid |
Target information
| Target ID | GM-MP2337 |
| Target Name | SSH1 |
| Gene ID | 54434,231637,304580,707809,477526,101094543,538233 |
| Gene Symbol and Synonyms | Gm1394,Gm1395,SSH-1,SSH-1L,SSH1,SSH1L |
| Uniprot Accession | Q8WYL5 |
| Uniprot Entry Name | SSH1_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000084112 |
| Target Classification | N/A |
The target: SSH1, gene name: SSH1, also named as SSH1L. The protein encoded by this gene belongs to the slingshot homolog (SSH) family of phosphatases, which regulate actin filament dynamics. The SSH proteins dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Cofilin is inactivated by kinases such as LIM domain kinase-1 (LIMK1), which may also be dephosphorylated and inactivated by SSH proteins. The SSH family thus appears to play a role in actin dynamics by reactivating cofilin proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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