Human CALM2/CALM/CALML2 ORF/cDNA clone-Lentivirus plasmid (NM_001743.5)

Cat. No.: pGMLP005410
Size: 10 µg
Concentration: generally 0.5ug/ul, usually not less than 0.3ug/ul
Leading Time: 3-7 working days

Pre-made Human CALM2/CALM/CALML2 Lentiviral expression plasmid for CALM2 lentivirus packaging, CALM2 lentivirus production, overexpression stable cell line development, cell transient transfection and gene delivery targeting T/B/NK cells, macrophages, cardiomyocytes, hepatocytes, and neurons.

Our GM-Lentiviral vector is seamlessly integrated with the GM lentivirus packaging system. Discover more about the GM lentivirus packaging system.

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Product Description

Catalog ID pGMLP005410
Gene Name CALM2
Accession Number NM_001743.5
Gene ID 805
Species Human
Product Type Lentivirus plasmid (overexpression)
Insert Length 450 bp
Gene Alias CALM,CALML2,caM,CAM1,CAM3,CAMC,CAMII,CAMIII,LQT15,PHKD,PHKD2
Fluorescent Reporter ZsGreen
Mammalian Cell Selection Puromyocin
Fusion Tag 3xflag (C-Terminal)
Promoter CMV
Resistance Amplicin
ORF Nucleotide Sequence ATGGCTGACCAACTGACTGAAGAGCAGATTGCAGAATTCAAAGAAGCTTTTTCACTATTTGACAAAGATGGTGATGGAACTATAACAACAAAGGAATTGGGAACTGTAATGAGATCTCTTGGGCAGAATCCCACAGAAGCAGAGTTACAGGACATGATTAATGAAGTAGATGCTGATGGTAATGGCACAATTGACTTCCCTGAATTTCTGACAATGATGGCAAGAAAAATGAAAGACACAGACAGTGAAGAAGAAATTAGAGAAGCATTCCGTGTGTTTGATAAGGATGGCAATGGCTATATTAGTGCTGCAGAACTTCGCCATGTGATGACAAACCTTGGAGAGAAGTTAACAGATGAAGAAGTTGATGAAATGATCAGGGAAGCAGATATTGATGGTGATGGTCAAGTAAACTATGAAGAGTTTGTACAAATGATGACAGCAAAGTGA
ORF Protein Sequence MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMTAK

Reference




    Data / case study


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    Associated products


    Category Cat No. Products Name
    Target Antibody GM-Tg-g-T39610-Ab Anti-CALM monoclonal antibody
    Target Antigen GM-Tg-g-T39610-Ag CALM/CALM2 protein
    ORF Viral Vector pGMLP005410 Human CALM2 Lentivirus plasmid
    ORF Viral Vector vGMLP005410 Human CALM2 Lentivirus particle


    Target information

    Target ID GM-T39610
    Target Name CALM
    Gene ID 805, 12314, 715270, 50663, 101081534, 474584, 100297344, 100629145
    Gene Symbol and Synonyms 1500001E21Rik,CALM,CALM2,CALM3,CALML2,calmodulin,caM,CAM1,Cam2,CAM3,Camb,CAMC,CAMII,CAMIII,LQT15,PHKD,PHKD2
    Uniprot Accession P0DP24
    Uniprot Entry Name CALM2_HUMAN
    Protein Sub-location Introcelluar Protein
    Category Therapeutics Target
    Disease Not Available
    Gene Ensembl ENSG00000143933
    Target Classification Not Available

    This gene is a member of the calmodulin gene family. There are three distinct calmodulin genes dispersed throughout the genome that encode the identical protein, but differ at the nucleotide level. Calmodulin is a calcium binding protein that plays a role in signaling pathways, cell cycle progression and proliferation. Several infants with severe forms of long-QT syndrome (LQTS) who displayed life-threatening ventricular arrhythmias together with delayed neurodevelopment and epilepsy were found to have mutations in either this gene or another member of the calmodulin gene family (PMID:23388215). Mutations in this gene have also been identified in patients with less severe forms of LQTS (PMID:24917665), while mutations in another calmodulin gene family member have been associated with catecholaminergic polymorphic ventricular tachycardia (CPVT)(PMID:23040497), a rare disorder thought to be the cause of a significant fraction of sudden cardiac deaths in young individuals. Pseudogenes of this gene are found on chromosomes 10, 13, and 17. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015]



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