Human BCL2L1/Bcl-X/BCL-XL/S ORF/cDNA clone-Lentivirus plasmid (NM_001322242.1)

Cat. No.: pGMLP005610
Size: 10 µg
Concentration: generally 0.5ug/ul, usually not less than 0.3ug/ul
Leading Time: 3-7 working days

Pre-made Human BCL2L1/Bcl-X/BCL-XL/S Lentiviral expression plasmid for BCL2L1 lentivirus packaging, BCL2L1 lentivirus production, overexpression stable cell line development, cell transient transfection and gene delivery targeting T/B/NK cells, macrophages, cardiomyocytes, hepatocytes, and neurons.

Our GM-Lentiviral vector is seamlessly integrated with the GM lentivirus packaging system. Discover more about the GM lentivirus packaging system.

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Product Description

Catalog ID pGMLP005610
Gene Name BCL2L1
Accession Number NM_001322242.1
Gene ID 598
Species Human
Product Type Lentivirus plasmid (overexpression)
Insert Length 702 bp
Gene Alias Bcl-X,BCL-XL/S,BCL2L,BCLX,PPP1R52
Fluorescent Reporter ZsGreen
Mammalian Cell Selection Puromyocin
Fusion Tag 3xflag (C-Terminal)
Promoter CMV
Resistance Amplicin
ORF Nucleotide Sequence ATGTCTCAGAGCAACCGGGAGCTGGTGGTTGACTTTCTCTCCTACAAGCTTTCCCAGAAAGGATACAGCTGGAGTCAGTTTAGTGATGTGGAAGAGAACAGGACTGAGGCCCCAGAAGGGACTGAATCGGAGATGGAGACCCCCAGTGCCATCAATGGCAACCCATCCTGGCACCTGGCAGACAGCCCCGCGGTGAATGGAGCCACTGGCCACAGCAGCAGTTTGGATGCCCGGGAGGTGATCCCCATGGCAGCAGTAAAGCAAGCGCTGAGGGAGGCAGGCGACGAGTTTGAACTGCGGTACCGGCGGGCATTCAGTGACCTGACATCCCAGCTCCACATCACCCCAGGGACAGCATATCAGAGCTTTGAACAGGTAGTGAATGAACTCTTCCGGGATGGGGTAAACTGGGGTCGCATTGTGGCCTTTTTCTCCTTCGGCGGGGCACTGTGCGTGGAAAGCGTAGACAAGGAGATGCAGGTATTGGTGAGTCGGATCGCAGCTTGGATGGCCACTTACCTGAATGACCACCTAGAGCCTTGGATCCAGGAGAACGGCGGCTGGGATACTTTTGTGGAACTCTATGGGAACAATGCAGCAGCCGAGAGCCGAAAGGGCCAGGAACGCTTCAACCGCTGGTTCCTGACGGGCATGACTGTGGCCGGCGTGGTTCTGCTGGGCTCACTCTTCAGTCGGAAATGA
ORF Protein Sequence MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK

Reference




    Data / case study


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    Associated products


    Category Cat No. Products Name
    Target Antibody GM-Tg-g-IP0048-Ab Anti-BCL-xL monoclonal antibody
    Target Antigen GM-Tg-g-IP0048-Ag BCL-xL/BCL2L1 protein
    ORF Viral Vector pGMLP000494 Human BCL2L1 Lentivirus plasmid
    ORF Viral Vector pGMLP005610 Human BCL2L1 Lentivirus plasmid
    ORF Viral Vector pGMLP005822 Human BCL2L1 Lentivirus plasmid
    ORF Viral Vector pGMAP000056 Human BCL2L1 Adenovirus plasmid
    ORF Viral Vector pGMPC001115 Human BCL2L1 Mammalian (Non-Viral Vector) plasmid
    ORF Viral Vector vGMLP000494 Human BCL2L1 Lentivirus particle
    ORF Viral Vector vGMLP005610 Human BCL2L1 Lentivirus particle
    ORF Viral Vector vGMLP005822 Human BCL2L1 Lentivirus particle
    ORF Viral Vector vGMAP000056 Human BCL2L1 Adenovirus particle


    Target information

    Target ID GM-IP0048
    Target Name BCL-xL
    Gene ID 598, 12048, 713035, 24888, 493701, 403618, 282152, 100053597
    Gene Symbol and Synonyms Bcl(X)L,Bcl-X,Bcl-XL,BCL-XL/S,bcl2-L-1,BCL2L,BCL2L1,BCLX,PPP1R52
    Uniprot Accession Q07817
    Uniprot Entry Name B2CL1_HUMAN
    Protein Sub-location Introcelluar Protein
    Category Therapeutics Target
    Disease Cancer
    Gene Ensembl ENSG00000171552
    Target Classification Tumor-associated antigen (TAA)

    The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Alternative splicing results in multiple transcript variants encoding two different isoforms. The longer isoform acts as an apoptotic inhibitor and the shorter isoform acts as an apoptotic activator. [provided by RefSeq, Dec 2015]



    About GMVC

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