Human TNFSF10/Apo-2L/APO2L ORF/cDNA clone-Mammalian (Non-Viral Vector) plasmid (NM_003810.3)

Cat. No.: pGMPC000026
Size: 10 µg
Concentration: generally 0.5ug/ul, usually not less than 0.3ug/ul
Leading Time: 3-7 working days

Pre-made Human TNFSF10/Apo-2L/APO2L Non-Viral expression plasmid (overexpression vector) for mouse TNFSF10 overexpression in unique cell transient transfection and stable cell line development.

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Product Description

Catalog ID pGMPC000026
Gene Name TNFSF10
Accession Number NM_003810.3
Gene ID 8743
Species Human
Product Type Mammalian (Non-Viral Vector) plasmid (overexpression)
Insert Length 846 bp
Gene Alias Apo-2L,APO2L,CD253,TL2,TNLG6A,TRAIL
Fluorescent Reporter EGFP
Mammalian Cell Selection Null
Fusion Tag 3xflag (C-Terminal)
Promoter EF1
Resistance Amplicin
ORF Nucleotide Sequence ATGGCTATGATGGAGGTCCAGGGGGGACCCAGCCTGGGACAGACCTGCGTGCTGATCGTGATCTTCACAGTGCTCCTGCAGTCTCTCTGTGTGGCTGTAACTTACGTGTACTTTACCAACGAGCTGAAGCAGATGCAGGACAAGTACTCCAAAAGTGGCATTGCTTGTTTCTTAAAAGAAGATGACAGTTATTGGGACCCCAATGACGAAGAGAGTATGAACAGCCCCTGCTGGCAAGTCAAGTGGCAACTCCGTCAGCTCGTTAGAAAGATGATTTTGAGAACCTCTGAGGAAACCATTTCTACAGTTCAAGAAAAGCAACAAAATATTTCTCCCCTAGTGAGAGAAAGAGGTCCTCAGAGAGTAGCAGCTCACATAACTGGGACCAGAGGAAGAAGCAACACATTGTCTTCTCCAAACTCCAAGAATGAAAAGGCTCTGGGCCGCAAAATAAACTCCTGGGAATCATCAAGGAGTGGGCATTCATTCCTGAGCAACTTGCACTTGAGGAATGGTGAACTGGTCATCCATGAAAAAGGGTTTTACTACATCTATTCCCAAACATACTTTCGATTTCAGGAGGAAATAAAAGAAAACACAAAGAACGACAAACAAATGGTCCAATATATTTACAAATACACAAGTTATCCTGACCCTATATTGTTGATGAAAAGTGCTAGAAATAGTTGTTGGTCTAAAGATGCAGAATATGGACTCTATTCCATCTATCAAGGGGGAATATTTGAGCTTAAGGAAAATGACAGAATTTTTGTTTCTGTAACAAATGAGCACTTGATAGACATGGACCATGAAGCCAGTTTTTTTGGGGCCTTTTTAGTTGGCTAA
ORF Protein Sequence MAMMEVQGGPSLGQTCVLIVIFTVLLQSLCVAVTYVYFTNELKQMQDKYSKSGIACFLKEDDSYWDPNDEESMNSPCWQVKWQLRQLVRKMILRTSEETISTVQEKQQNISPLVRERGPQRVAAHITGTRGRSNTLSSPNSKNEKALGRKINSWESSRSGHSFLSNLHLRNGELVIHEKGFYYIYSQTYFRFQEEIKENTKNDKQMVQYIYKYTSYPDPILLMKSARNSCWSKDAEYGLYSIYQGGIFELKENDRIFVSVTNEHLIDMDHEASFFGAFLVG

Reference




    Data / case study


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    Associated products


    Category Cat No. Products Name
    Target Antibody GM-Tg-g-T46084-Ab Anti-TNF10/ TNFSF10/ APO2L functional antibody
    Target Antigen GM-Tg-g-T46084-Ag TNFSF10 protein
    Cytokine cks-Tg-g-GM-T46084 tumor necrosis factor (ligand) superfamily, member 10 (TNFSF10) protein & antibody
    ORF Viral Vector pGMPC000026 Human TNFSF10 Mammalian (Non-Viral Vector) plasmid
    ORF Viral Vector pGMPC000692 Human TNFSF10 Mammalian (Non-Viral Vector) plasmid


    Target information

    Target ID GM-T46084
    Target Name TNFSF10
    Gene ID 8743, 22035, 694451, 246775, 100174789, 100174780, 507215, 100064377
    Gene Symbol and Synonyms A330042I21Rik,Apo-2L,APO2L,CD253,Ly81,TANCR,TL2,TNFSF10,TNLG6A,TRAIL
    Uniprot Accession P50591
    Uniprot Entry Name TNF10_HUMAN
    Protein Sub-location Secreted Protein/Potential Cytokines
    Category Therapeutics Target, Immuno-oncology Target, Cytokine Target
    Disease Prostate Cancer
    Gene Ensembl ENSG00000121858
    Target Classification Checkpoint-Immuno Oncology

    The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]



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