Recombinant multi-species TNF10/ TNFSF10/ APO2L protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine TNFSF10 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

The target: TNFSF10, gene name: TNFSF10, also named as APO2L, Apo-2L, CD253, TL2, TNLG6A, TRAIL. The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010].

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Catalog No.	Product Name	Species	Size	Price
GM-Tg-hg-T46084-Ag-1	Human TNFSF10 protein	Human	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-rg-T46084-Ag-1	Rat TNFSF10 protein	Rat	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-mg-T46084-Ag-1	Mouse TNFSF10 protein	Mouse	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-cynog-T46084-Ag-1	Cynomolgus/ Rhesus macaque TNFSF10 protein	Cynomolgus/ Rhesus macaque	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-felg-T46084-Ag-1	Feline TNFSF10 protein	Feline	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-cang-T46084-Ag-1	Canine TNFSF10 protein	Canine	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-bovg-T46084-Ag-1	Bovine TNFSF10 protein	Bovine	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-bovg-T46084-Ag-1	Equine TNFSF10 protein	Equine	1mg/10mg/100mg/≥100mg	Inquiry
Shipping Cost:				760.00

Description

Catalog No.	GM-Tg-hg-T46084-Ag, GM-Tg-rg-T46084-Ag, GM-Tg-mg-T46084-Ag, GM-Tg-cynog-T46084-Ag, GM-Tg-felg-T46084-Ag, GM-Tg-cang-T46084-Ag, GM-Tg-bovg-T46084-Ag, GM-Tg-equg-T46084-Ag-1
Products Name	TNFSF10 protein
Species	Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name	TNFSF10
Protein Sub-location	Secreted Protein/Potential Cytokines
Isotypes	Recombinant protein
Expression platform	Mammalian cell
Bioactivity validation	Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag	His
Products description	Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine TNFSF10 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity	Purity: ≥95% (SDS-PAGE)
Application	In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation	Supplied as a 0.2 μM filtered solution of PBS, PH7.4.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.