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Anti-TNF10/ TNFSF10/ APO2L functional antibody
Anti-TNF10/ TNFSF10/ APO2L functional antibody for cell culture, ELISA & in-vivo assay
Go to TNFSF10/TNFSF10 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T46084-Ab-1/ GM-Tg-hg-T46084-Ab-2 | Anti-Human TNFSF10 monoclonal antibody | Human |
| GM-Tg-rg-T46084-Ab-1/ GM-Tg-rg-T46084-Ab-2 | Anti-Rat TNFSF10 monoclonal antibody | Rat |
| GM-Tg-mg-T46084-Ab-1/ GM-Tg-mg-T46084-Ab-2 | Anti-Mouse TNFSF10 monoclonal antibody | Mouse |
| GM-Tg-cynog-T46084-Ab-1/ GM-Tg-cynog-T46084-Ab-2 | Anti-Cynomolgus/ Rhesus macaque TNFSF10 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T46084-Ab-1/ GM-Tg-felg-T46084-Ab-2 | Anti-Feline TNFSF10 monoclonal antibody | Feline |
| GM-Tg-cang-T46084-Ab-1/ GM-Tg-cang-T46084-Ab-2 | Anti-Canine TNFSF10 monoclonal antibody | Canine |
| GM-Tg-bovg-T46084-Ab-1/ GM-Tg-bovg-T46084-Ab-2 | Anti-Bovine TNFSF10 monoclonal antibody | Bovine |
| GM-Tg-equg-T46084-Ab-1/ GM-Tg-equg-T46084-Ab-2 | Anti-Equine TNFSF10 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T46084-Ab-1/ GM-Tg-hg-T46084-Ab-2; GM-Tg-rg-T46084-Ab-1/ GM-Tg-rg-T46084-Ab-2; GM-Tg-mg-T46084-Ab-1/ GM-Tg-mg-T46084-Ab-2; GM-Tg-cynog-T46084-Ab-1/ GM-Tg-cynog-T46084-Ab-2; GM-Tg-felg-T46084-Ab-1/ GM-Tg-felg-T46084-Ab-2; GM-Tg-cang-T46084-Ab-1/ GM-Tg-cang-T46084-Ab-2; GM-Tg-bovg-T46084-Ab-1/ GM-Tg-bovg-T46084-Ab-2; GM-Tg-equg-T46084-Ab-1/ GM-Tg-equg-T46084-Ab-2 |
| Products Name | Anti-TNFSF10 monoclonal antibody |
| Format | mab |
| Target Name | TNFSF10 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-TNFSF10 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T46084-Ag-1 | Recombinant multi-species TNF10/ TNFSF10/ APO2L protein |
| Cytokine | GM-Tg-g-T46084-Ag-1 | tumor necrosis factor (ligand) superfamily, member 10 (TNFSF10) protein |
| ORF Viral Vector | pGMLPm001935 | mouse Tnfsf10 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm001935 | mouse Tnfsf10 Lentivirus particle |
Target information
| Target ID | GM-T46084 |
| Target Name | TNFSF10 |
| Gene ID | 8743,22035,246775,694451,100174780,100174789,507215,100064377 |
| Gene Symbol and Synonyms | A330042I21Rik,Apo-2L,APO2L,CD253,Ly81,TANCR,TL2,TNFSF10,TNLG6A,TRAIL |
| Uniprot Accession | P50591 |
| Uniprot Entry Name | TNF10_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target, Immuno-oncology Target, Cytokine Target |
| Disease | Prostate Cancer |
| Gene Ensembl | ENSG00000121858 |
| Target Classification | Checkpoint-Immuno Oncology |
The target: TNFSF10, gene name: TNFSF10, also named as APO2L, Apo-2L, CD253, TL2, TNLG6A, TRAIL. The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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