Human OLR1/CLEC8A/LOX1 ORF/cDNA clone-Mammalian (Non-Viral Vector) plasmid (NM_002543.4)

Cat. No.: pGMPC001400
Size: 10 µg
Concentration: generally 0.5ug/ul, usually not less than 0.3ug/ul
Leading Time: 3-7 working days

Pre-made Human OLR1/CLEC8A/LOX1 Non-Viral expression plasmid (overexpression vector) for mouse OLR1 overexpression in unique cell transient transfection and stable cell line development.

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Product Description

Catalog ID pGMPC001400
Gene Name OLR1
Accession Number NM_002543.4
Gene ID 4973
Species Human
Product Type Mammalian (Non-Viral Vector) plasmid (overexpression)
Insert Length 822 bp
Gene Alias CLEC8A,LOX1,LOXIN,SCARE1,SLOX1
Fluorescent Reporter EGFP
Mammalian Cell Selection Null
Fusion Tag 3xflag (C-Terminal)
Promoter EF1
Resistance Amplicin
ORF Nucleotide Sequence ATGACTTTTGATGACCTAAAGATCCAGACTGTGAAGGACCAGCCTGATGAGAAGTCAAATGGAAAAAAAGCTAAAGGTCTTCAGTTTCTTTACTCTCCATGGTGGTGCCTGGCTGCTGCGACTCTAGGGGTCCTTTGCCTGGGATTAGTAGTGACCATTATGGTGCTGGGCATGCAATTATCCCAGGTGTCTGACCTCCTAACACAAGAGCAAGCAAACCTAACTCACCAGAAAAAGAAACTGGAGGGACAGATCTCAGCCCGGCAACAAGCAGAAGAAGCTTCACAGGAGTCAGAAAACGAACTCAAGGAAATGATAGAAACCCTTGCTCGGAAGCTGAATGAGAAATCCAAAGAGCAAATGGAACTTCACCACCAGAATCTGAATCTCCAAGAAACACTGAAGAGAGTAGCAAATTGTTCAGCTCCTTGTCCGCAAGACTGGATCTGGCATGGAGAAAACTGTTACCTATTTTCCTCGGGCTCATTTAACTGGGAAAAGAGCCAAGAGAAGTGCTTGTCTTTGGATGCCAAGTTGCTGAAAATTAATAGCACAGCTGATCTGGACTTCATCCAGCAAGCAATTTCCTATTCCAGTTTTCCATTCTGGATGGGGCTGTCTCGGAGGAACCCCAGCTACCCATGGCTCTGGGAGGACGGTTCTCCTTTGATGCCCCACTTATTTAGAGTCCGAGGCGCTGTCTCCCAGACATACCCTTCAGGTACCTGTGCATATATACAACGAGGAGCTGTTTATGCGGAAAACTGCATTTTAGCTGCCTTCAGTATATGTCAGAAGAAGGCAAACCTAAGAGCACAGTGA
ORF Protein Sequence MTFDDLKIQTVKDQPDEKSNGKKAKGLQFLYSPWWCLAAATLGVLCLGLVVTIMVLGMQLSQVSDLLTQEQANLTHQKKKLEGQISARQQAEEASQESENELKEMIETLARKLNEKSKEQMELHHQNLNLQETLKRVANCSAPCPQDWIWHGENCYLFSSGSFNWEKSQEKCLSLDAKLLKINSTADLDFIQQAISYSSFPFWMGLSRRNPSYPWLWEDGSPLMPHLFRVRGAVSQTYPSGTCAYIQRGAVYAENCILAAFSICQKKANLRAQ

Reference




    Data / case study


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    Associated products


    Category Cat No. Products Name
    Target Antibody GM-Tg-g-T49630-Ab Anti-OLR1/ CLEC8A/ LOX1 monoclonal antibody
    Target Antigen GM-Tg-g-T49630-Ag OLR1 VLP (virus-like particle)
    ORF Viral Vector pGMLP000723 Human OLR1 Lentivirus plasmid
    ORF Viral Vector pGMLV002554 Human OLR1 Lentivirus plasmid
    ORF Viral Vector pGMPC001398 Human OLR1 Mammalian (Non-Viral Vector) plasmid
    ORF Viral Vector pGMPC001400 Human OLR1 Mammalian (Non-Viral Vector) plasmid
    ORF Viral Vector vGMLP000723 Human OLR1 Lentivirus particle
    ORF Viral Vector vGMLV002554 Human OLR1 Lentivirus particle


    Target information

    Target ID GM-T49630
    Target Name OLR1
    Gene ID 4973, 108078, 717596, 140914, 101086238, 486694, 281368, 100062370
    Gene Symbol and Synonyms CLEC8A,LOX-1,LOX1,LOXIN,Oldlr1,Oldr1,OLR1,SCARE1,SLOX1,SR-EI
    Uniprot Accession P78380
    Uniprot Entry Name OLR1_HUMAN
    Protein Sub-location Transmembrane Protein
    Category Therapeutics Target
    Disease Not Available
    Gene Ensembl ENSG00000173391
    Target Classification Not Available

    This gene encodes a low density lipoprotein receptor that belongs to the C-type lectin superfamily. This gene is regulated through the cyclic AMP signaling pathway. The encoded protein binds, internalizes and degrades oxidized low-density lipoprotein. This protein may be involved in the regulation of Fas-induced apoptosis. This protein may play a role as a scavenger receptor. Mutations of this gene have been associated with atherosclerosis, risk of myocardial infarction, and may modify the risk of Alzheimer's disease. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010]



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