Human IL10/CSIF/GVHDS ORF/cDNA clone-Adenovirus particle (NM_000572.2)

Cat. No.: vGMAD000014

Pre-made Human IL10/CSIF/GVHDS Adenovirus for IL10 overexpression in-vitro and in-vivo. The IL10 adenoviral vector excels as a vehicle for transient gene transfection in both stable cell lines and primary cells, including DC cells, macrophages, cardiomyocytes, hepatocytes, and neurons. The purified IL10-encoding adenovirus also stands out as a quintessential tool for in vivo studies and vaccine research initiatives.

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Target products collection

Go to IL10/CSIF products collection>>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Adenovirus Grade Adenovirus quantity
vGMAD000014 Human IL10 Adenovirus particle Research Grade-In vitro 1E+10PFU (1E+10pfu/ml×1ml)
5E+10PFU (1E+10pfu/ml×5ml)
1E+11PFU (1E+10pfu/ml×10ml)
Research Grade-In vivo 1E+11PFU (1E+11pfu/ml×1ml)
GMP-like Grade inquiry
GMP Grade inquiry


Product Description

Catalog ID vGMAD000014
Gene Name IL10
Accession Number NM_000572.2
Gene ID 3586
Species Human
Product Type Adenovirus particle (overexpression)
Insert Length 537 bp
Gene Alias CSIF,GVHDS,IL-10,IL10A,TGIF
Fluorescent Reporter Null
Mammalian Cell Selection Null
Fusion Tag 3xflag (C-Terminal)
Promoter CMV
Resistance Amplicin
ORF Nucleotide Sequence ATGCACAGCTCAGCACTGCTCTGTTGCCTGGTCCTCCTGACTGGGGTGAGGGCCAGCCCAGGCCAGGGCACCCAGTCTGAGAACAGCTGCACCCACTTCCCAGGCAACCTGCCTAACATGCTTCGAGATCTCCGAGATGCCTTCAGCAGAGTGAAGACTTTCTTTCAAATGAAGGATCAGCTGGACAACTTGTTGTTAAAGGAGTCCTTGCTGGAGGACTTTAAGGGTTACCTGGGTTGCCAAGCCTTGTCTGAGATGATCCAGTTTTACCTGGAGGAGGTGATGCCCCAAGCTGAGAACCAAGACCCAGACATCAAGGCGCATGTGAACTCCCTGGGGGAGAACCTGAAGACCCTCAGGCTGAGGCTACGGCGCTGTCATCGATTTCTTCCCTGTGAAAACAAGAGCAAGGCCGTGGAGCAGGTGAAGAATGCCTTTAATAAGCTCCAAGAGAAAGGCATCTACAAAGCCATGAGTGAGTTTGACATCTTCATCAACTACATAGAAGCCTACATGACAATGAAGATACGAAACTGA
ORF Protein Sequence MHSSALLCCLVLLTGVRASPGQGTQSENSCTHFPGNLPNMLRDLRDAFSRVKTFFQMKDQLDNLLLKESLLEDFKGYLGCQALSEMIQFYLEEVMPQAENQDPDIKAHVNSLGENLKTLRLRLRRCHRFLPCENKSKAVEQVKNAFNKLQEKGIYKAMSEFDIFINYIEAYMTMKIRN

Reference




    Data / case study


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    Associated products


    Category Cat No. Products Name
    Target Antibody GM-Tg-g-T09092-Ab Anti-IL10/ CSIF/ GVHDS functional antibody
    Target Antigen GM-Tg-g-T09092-Ag IL10 protein
    Cytokine cks-Tg-g-GM-T09092 interleukin 10 (IL10) protein & antibody
    ORF Viral Vector pGMLV001166 Human IL-10 Lentivirus plasmid
    ORF Viral Vector pGMAD000014 Human IL10 Adenovirus plasmid
    ORF Viral Vector pGMAP000484 Human IL10 Adenovirus plasmid
    ORF Viral Vector pGMLP-IL-013 Human IL10 Lentivirus plasmid
    ORF Viral Vector pGMAP-IL-096 Human IL10 Adenovirus plasmid
    ORF Viral Vector pGMPC004770 Human IL10 Mammalian (Non-Viral Vector) plasmid
    ORF Viral Vector vGMLV001166 Human IL-10 Lentivirus particle
    ORF Viral Vector vGMAD000014 Human IL10 Adenovirus particle
    ORF Viral Vector vGMAP000484 Human IL10 Adenovirus particle
    ORF Viral Vector vGMLP-IL-013 Human IL10 Lentivirus particle
    ORF Viral Vector vGMAP-IL-096 Human IL10 Adenovirus particle


    Target information

    Target ID GM-T09092
    Target Name IL10
    Gene ID 3586, 16153, 694931, 25325, 493683, 403628, 281246, 100034187
    Gene Symbol and Synonyms CSIF,GVHDS,If2a,IL-10,IL10,IL10A,IL10X,TGIF
    Uniprot Accession P22301
    Uniprot Entry Name IL10_HUMAN
    Protein Sub-location Secreted Protein/Potential Cytokines
    Category Therapeutics Target, Immuno-oncology Target, Cytokine Target
    Disease Ovary Cancer, metastases, asthma, Malignant neoplasm of bladder
    Gene Ensembl ENSG00000136634
    Target Classification Checkpoint-Immuno Oncology

    The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. [provided by RefSeq, May 2020]



    About GMVC

    GDU

    GMVC (GM Vector Core) is GeneMedi’s unique platform for QbD Viral vectors Processes development and manufacturing. In GMVC, our core expertise lies in the tailored production of viral vectors, including adeno-associated virus (AAV), lentivirus, and adenovirus. Our state-of-the-art facilities are equipped for scalable manufacturing, ensuring high-quality viral vector production to meet both research and therapeutic needs. Our expert team specializes in process development, leveraging innovative technology and extensive industry knowledge to provide clients with tailored solutions that exceed expectations. GMVC will be the ideal partner for scientists and healthcare professionals seeking reliable and efficient viral vector production services.