Human DNMT3B/ICF/ ICF1 ORF/cDNA clone-Adenovirus particle (NM_006892.3)
Pre-made Human DNMT3B/ICF/ ICF1 Adenovirus for DNMT3B overexpression in-vitro and in-vivo. The DNMT3B adenoviral vector excels as a vehicle for transient gene transfection in both stable cell lines and primary cells, including DC cells, macrophages, cardiomyocytes, hepatocytes, and neurons. The purified DNMT3B-encoding adenovirus also stands out as a quintessential tool for in vivo studies and vaccine research initiatives.
At GM Vector Core (GMVC), we provide bespoke adenovirus development and manufacture various grades of adenoviruses utilizing cutting-edge techniques. Dive deeper into our offerings.
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Product information
Catalog No. | Product Name | Adenovirus Grade | Adenovirus quantity |
vGMAD000196 | Human DNMT3B Adenovirus particle | Research Grade-In vitro | 1E+10PFU (1E+10pfu/ml×1ml) |
5E+10PFU (1E+10pfu/ml×5ml) | |||
1E+11PFU (1E+10pfu/ml×10ml) | |||
Research Grade-In vivo | 1E+11PFU (1E+11pfu/ml×1ml) | ||
GMP-like Grade | inquiry | ||
GMP Grade | inquiry |
Product Description
Catalog ID | vGMAD000196 |
Gene Name | DNMT3B |
Accession Number | NM_006892.3 |
Gene ID | 1789 |
Species | Human |
Product Type | Adenovirus particle (overexpression) |
Insert Length | 2562 bp |
Gene Alias | ICF, ICF1, M.HsaIIIB |
Fluorescent Reporter | EGFP |
Mammalian Cell Selection | |
Fusion Tag | 3xflag (C-Terminal) |
Promoter | CMV |
Resistance | Amplicin |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Category | Cat No. | Products Name |
---|---|---|
Target Antibody | GM-Tg-g-T65501-Ab | Anti-DNMT3B monoclonal antibody |
Target Antigen | GM-Tg-g-T65501-Ag | DNMT3B protein |
ORF Viral Vector | pGMAD000196 | Human DNMT3B Adenovirus plasmid |
ORF Viral Vector | vGMAD000196 | Human DNMT3B Adenovirus particle |
ORF Viral Vector | pGMLV002457 | Human DNMT3B Lentivirus plasmid |
Target information
Target ID | GM-T65501 |
Target Name | DNMT3B |
Gene ID | 1789, 13436, 711553, 444985, 101092926, 100685634, 353354, 100053900 |
Gene Symbol and Synonyms | DNMT3B,FSHD4,ICF,ICF1,M.HsaIIIB,MmuIIIB |
Uniprot Accession | Q9UBC3 |
Uniprot Entry Name | DNM3B_HUMAN |
Protein Sub-location | Introcelluar Protein |
Category | Therapeutics Target |
Disease | Cancer |
Gene Ensembl | ENSG00000088305 |
Target Classification | Tumor-associated antigen (TAA) |
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Eight alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined. [provided by RefSeq, May 2011]
About GMVC
GMVC (GM Vector Core) is GeneMedi’s unique platform for QbD Viral vectors Processes development and manufacturing. In GMVC, our core expertise lies in the tailored production of viral vectors, including adeno-associated virus (AAV), lentivirus, and adenovirus. Our state-of-the-art facilities are equipped for scalable manufacturing, ensuring high-quality viral vector production to meet both research and therapeutic needs. Our expert team specializes in process development, leveraging innovative technology and extensive industry knowledge to provide clients with tailored solutions that exceed expectations. GMVC will be the ideal partner for scientists and healthcare professionals seeking reliable and efficient viral vector production services.