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Anti-DNMT3B monoclonal antibody
Pre-made anti-DNMT3B monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to DNMT3B/DNMT3B products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T65501-Ab-1/ GM-Tg-hg-T65501-Ab-2 | Anti-Human DNMT3B monoclonal antibody | Human |
| GM-Tg-rg-T65501-Ab-1/ GM-Tg-rg-T65501-Ab-2 | Anti-Rat DNMT3B monoclonal antibody | Rat |
| GM-Tg-mg-T65501-Ab-1/ GM-Tg-mg-T65501-Ab-2 | Anti-Mouse DNMT3B monoclonal antibody | Mouse |
| GM-Tg-cynog-T65501-Ab-1/ GM-Tg-cynog-T65501-Ab-2 | Anti-Cynomolgus/ Rhesus macaque DNMT3B monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T65501-Ab-1/ GM-Tg-felg-T65501-Ab-2 | Anti-Feline DNMT3B monoclonal antibody | Feline |
| GM-Tg-cang-T65501-Ab-1/ GM-Tg-cang-T65501-Ab-2 | Anti-Canine DNMT3B monoclonal antibody | Canine |
| GM-Tg-bovg-T65501-Ab-1/ GM-Tg-bovg-T65501-Ab-2 | Anti-Bovine DNMT3B monoclonal antibody | Bovine |
| GM-Tg-equg-T65501-Ab-1/ GM-Tg-equg-T65501-Ab-2 | Anti-Equine DNMT3B monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T65501-Ab-1/ GM-Tg-hg-T65501-Ab-2; GM-Tg-rg-T65501-Ab-1/ GM-Tg-rg-T65501-Ab-2; GM-Tg-mg-T65501-Ab-1/ GM-Tg-mg-T65501-Ab-2; GM-Tg-cynog-T65501-Ab-1/ GM-Tg-cynog-T65501-Ab-2; GM-Tg-felg-T65501-Ab-1/ GM-Tg-felg-T65501-Ab-2; GM-Tg-cang-T65501-Ab-1/ GM-Tg-cang-T65501-Ab-2; GM-Tg-bovg-T65501-Ab-1/ GM-Tg-bovg-T65501-Ab-2; GM-Tg-equg-T65501-Ab-1/ GM-Tg-equg-T65501-Ab-2 |
| Products Name | Anti-DNMT3B monoclonal antibody |
| Format | mab |
| Target Name | DNMT3B |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-DNMT3B monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T65501-Ag-1 | Recombinant multi-species DNM3B/ DNMT3B/ ICF protein |
| ORF Viral Vector | pGMAD000196 | human DNMT3B Adenovirus plasmid |
| ORF Viral Vector | vGMAD000196 | human DNMT3B Adenovirus particle |
| ORF Viral Vector | pGMLPm004826 | mouse Dnmt3b Lentivirus plasmid |
| ORF Viral Vector | vGMLPm004826 | mouse Dnmt3b Lentivirus particle |
Target information
| Target ID | GM-T65501 |
| Target Name | DNMT3B |
| Gene ID | 1789,13436,444985,711553,100685634,101092926,353354,100053900 |
| Gene Symbol and Synonyms | DNMT3B,FSHD4,ICF,ICF1,M.HsaIIIB,MmuIIIB |
| Uniprot Accession | Q9UBC3 |
| Uniprot Entry Name | DNM3B_HUMAN |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000088305 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: DNMT3B, gene name: DNMT3B, also named as ICF, ICF1, M.HsaIIIB. CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Eight alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined. [provided by RefSeq, May 2011].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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