Recombinant multi-species DNM3B/ DNMT3B/ ICF protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine DNMT3B protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

The target: DNMT3B, gene name: DNMT3B, also named as ICF, ICF1, M.HsaIIIB. CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Eight alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined. [provided by RefSeq, May 2011].

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Catalog No.	Product Name	Species	Size	Price
GM-Tg-hg-T65501-Ag-1	Human DNMT3B protein	Human	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-rg-T65501-Ag-1	Rat DNMT3B protein	Rat	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-mg-T65501-Ag-1	Mouse DNMT3B protein	Mouse	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-cynog-T65501-Ag-1	Cynomolgus/ Rhesus macaque DNMT3B protein	Cynomolgus/ Rhesus macaque	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-felg-T65501-Ag-1	Feline DNMT3B protein	Feline	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-cang-T65501-Ag-1	Canine DNMT3B protein	Canine	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-bovg-T65501-Ag-1	Bovine DNMT3B protein	Bovine	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-bovg-T65501-Ag-1	Equine DNMT3B protein	Equine	1mg/10mg/100mg/≥100mg	Inquiry
Shipping Cost:				760.00

Description

Catalog No.	GM-Tg-hg-T65501-Ag, GM-Tg-rg-T65501-Ag, GM-Tg-mg-T65501-Ag, GM-Tg-cynog-T65501-Ag, GM-Tg-felg-T65501-Ag, GM-Tg-cang-T65501-Ag, GM-Tg-bovg-T65501-Ag, GM-Tg-equg-T65501-Ag-1
Products Name	DNMT3B protein
Species	Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name	DNMT3B
Protein Sub-location	Introcelluar Protein
Isotypes	Recombinant protein
Expression platform	Mammalian cell
Bioactivity validation	Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag	His
Products description	Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine DNMT3B protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity	Purity: ≥95% (SDS-PAGE)
Application	In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation	Supplied as a 0.2 μM filtered solution of PBS, PH7.4.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.