Equine p-tau202 and 205 antibody and antigen (recombinant protein)

Diagnostic anti-Equine p-tau202 and 205 antibodies pairs and antigen for animal health (animal Equine/Horse Alzheimer Disease(AD)) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

Target products collection Go to Equine disease testing products collection >>

Product information

Catalog No.	Description	US $ Price (per mg)
GMP-EQU-p-tau202-205-Ag01	Equine p-tau202 and 205	$3090.00
GMP-EQU-p-tau202-205-Ab01	Anti-Equine p-tau202 and 205 mouse monoclonal antibody (mAb)	$3090.00
GMP-EQU-p-tau202-205-Ab02	Anti-Equine p-tau202 and 205 mouse monoclonal antibody (mAb)	$3090.00
GMP-EQU-p-tau202-205-Ab03	Anti-Equine p-tau202 and 205 human monoclonal antibody (mAb)	$3090.00
GMP-EQU-p-tau202-205-Ab04	Anti-Equine p-tau202 and 205 human monoclonal antibody (mAb)	$3090.00

Size： 1mg | 10mg | 100mg

Product Description

Cat No.	GMP-EQU-p-tau202-205-Ag01
Product Name	Equine p-tau202 and 205
Target/Biomarker	Equine p-tau202 and 205
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Equine p-tau202 and 205 antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in p-tau202 and 205 level test of animal Equine/Horse with Alzheimer Disease(AD).
Tag	His
Reconized/Reactive Specics	Equine p-tau202 and 205
Product description	Recombinant Equine p-tau202 and 205 protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-EQU-p-tau202-205-Ab01,GMP-EQU-p-tau202-205-Ab02
Target/Biomarker	Equine p-tau202 and 205
Product Name	Anti-Equine p-tau202 and 205 mouse monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Equine p-tau202 and 205 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Equine p-tau202 and 205 antibodies in Equine p-tau202 and 205 level test of animal Equine/Horse with Alzheimer Disease(AD).
Product description	Anti-Equine p-tau202 and 205 mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Equine p-tau202 and 205 antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-EQU-p-tau202-205-Ab03,GMP-EQU-p-tau202-205-Ab04
Target/Biomarker	Equine p-tau202 and 205
Product Name	Anti-Equine p-tau202 and 205 human monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Human lgG1
Bioactivity validation	Recombinant Equine p-tau202 and 205 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Equine p-tau202 and 205 antibodies in Equine p-tau202 and 205 level test of animal Equine/Horse with Alzheimer Disease(AD).
Product description	Anti-Equine p-tau202 and 205 mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Target/Biomarker Information

Equine p-tau202 and p-tau205, the phosphorylated Tau Proteins unique to horses, occupy a distinctive position within the intricate mosaic of equine neurobiology. At their core, they are Tau proteins that have undergone specific biochemical modifications – phosphorylation – at residues 202 and 205. Under normal circumstances, Tau proteins in horses play a pivotal role in stabilizing microtubules, crucial for axonal stability and intracellular transport within neuronal cells.

However, the narrative transforms in the context of neurodegenerative diseases. Phosphorylation events trigger the misfolding and aggregation of Tau proteins, and in the equine species, p-tau202 and p-tau205 tend to aggregate and form neurofibrillary tangles (NFTs) within neural tissues.

These NFTs, analogous to those observed in human neurodegenerative diseases such as Alzheimer's, represent a pathological signature of several equine neurodegenerative conditions. The accumulation of p-tau202 and p-tau205 in NFTs contributes to progressive neuronal dysfunction, altered behavior, and motor disturbances characteristic of conditions like equine neuroaxonal dystrophy (eNAD) and specific encephalopathies.

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