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Alzheimer Disease(AD) Recent publications and meeting presentations bolster the evidence that upticks in p-tau181, p-tau217, and p-tau231 occur soon after Aβ begins to accumulate in the brain. That’s years before neurofibrillary tangles can be detected by PET, and decades before symptoms. Researchers predict these markers, which also distinguish AD from other forms of dementia, will lead to more robust tests than those based on Aβ, because of their larger dynamic range—phosphorylated fragments of tau climb by as much as 10-fold in the blood as AD progresses, whereas the Aβ42/40 ratio falls by about 15 percent at most.

Genemedi produces core diagnostic ingredients for test of Neuropathy and related syndrome. GeneMedi offers paired diagnostics grade Phospho-tau181 (p-tau181) antibodies (monoclonal antibody,mab)and Phospho-tau181 (p-tau181) antigens for Neuropathy rapid test kit of Phospho-tau181 (p-tau181) testing in ELISA test,Lateral flow immunoassay (LFIA),colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA),turbidimetric inhibition immuno assay (TINIA),immunonephelometry and POCT.

All the antibodies and antigens for Neuropathy test are suitable for in functional ELISA, and other immunoassays in dignostics.The antibodies can act as a capture antibody and detection antibody.The antigens can be used for antibodies rapid test of Neuropathy.



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Delivery impact due to the Coronavirus Outbreak

With the COVID-19 outbreak in the world, many flights have been cancelled. In order for the customer to receive the goods properly, we use the FedEx Customized Freight (FCF) of Fedex which demands a higher fee. If the delivery fee is more expensive in your area, we will contact you by mail.

Catalog No. Size Price(In USD) Qty (Quantity) Sum(In USD)
GMP-p-tau181-Ab-1 Size:1mg 1953
GMP-p-tau181-Ab-1 Size:10mg 13671
GMP-p-tau181-Ab-1 Size:100mg 95697
GMP-p-tau181-Ab-2 Size:1mg 1953
GMP-p-tau181-Ab-2 Size:10mg 13671
GMP-p-tau181-Ab-2 Size:100mg 95697
GMP-p-tau181-Ab ≥100mg Inquiry
Shipping Cost: 760.00
Total:



Description


Cat No. GMP-p-tau181-Ab-1; GMP-p-tau181-Ab-2
Product Name Anti-Phospho-tau181 (p-tau181) mouse monoclonal antibody(mAb)
Expression platform Hybridoma
IsotypesMouse IgG
Bioactivity validationHuman Phospho-tau181 (p-tau181) protein binding, ELISA validated as capture antibody. Pair in p-tau181level test and Neuropathy evaluation.
TagmFc
Products descriptionAnti-Phospho-tau181 (p-tau181) mouse monoclonal antibody(mAb) is a mouse monoclonal antibody produced by hybridoma technology. The antibody is ELISA validated as capture antibody and detection antibody pair.
Specicsmouse
PurityPurity: ≥95% (SDS-PAGE)
Application ELISA test,Lateral flow immunoassay (LFIA),colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA),turbidimetric inhibition immuno assay (TINIA) and Immunonephelometry.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


GeneMedi's p-tau217/Tau and p-tau181/Tau antibody pairs show good performance in serological diagnosis of Alzheimer's Disease (AD) blood test

Established biomarkers for Alzheimer’s disease, including beta-amyloid (Aβ) and tau. Compared with CSF-based measurements, blood-based biomarkers have the potential to be deployed widely due to the lower costs and less invasiveness. Decreased beta-amyloid 42/beta-amyloid 40(Aβ42/Aβ40) ratio and increased p-tau217 and p-tau181 were associated with subsequent Alzheimer’s disease diagnosis1. Both p-tau217 and p-tau181 had an excellent diagnostic performance for differentiating patients with Alzheimer’s disease syndromes from other neurodegenerative disorders. Besides, P-tau217 was a stronger indicator than p-tau1812.

GeneMedi's p-tau217/Tau and p-tau181/Tau antibody pairs show good performance in diagnosis of Alzheimer's Disease blood test. Recently, Eli Lilly's P-tau217 Serological Test also showed high accuracy in diagnosis of Alzheimer's Disease, which was published in JAMA.

Cat No. Antibody/Antigen Name
GMP-p-tau217-Ab Anti-Phospho-tau217 (p-tau217) mouse monoclonal antibody(mAb)
GMP-p-tau217-antigen Phospho-tau217 (p-tau217) antigen (positive control)
GMP-p-tau181-Ab Anti-Phospho-tau181 (p-tau181) mouse monoclonal antibody(mAb)
GMP-p-tau181-antigen Phospho-tau181 (p-tau181) antigen (positive control)
GMP-Tau-Ab Anti-tau proteins (tau) mouse monoclonal antibody(mAb)

Reference

[1] Adam M. Brickman. Plasma p-tau181, p-tau217, and other blood-based Alzheimer’s disease biomarkers in a multi-ethnic, community study. Alzheimer’s Dement. 2021;17:1353–1364.
[2] Elisabeth H Thijssen. Plasma phosphorylated tau 217 and phosphorylated tau 181 as biomarkers in Alzheimer’s disease and frontotemporal lobar degeneration: a retrospective diagnostic performance study. Lancet Neurol 2021; 20: 739–52.