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It's the GeneMedi's summary page for Target/Biomarker Introduction of IL17,IL17A. The page also collects GeneMedi's different modalities and formats products for IL17 in therapeutics/drug discovery and IVD diagnostics, which is including antibody, ADC, bispecific, antigen, ORF vector, VLP, etc. With GeneMedi's target-insight database-GM ITD database, the IL17 target is also connected to human indications/diseases/conditions/MOA.

Target sublocation: Secreted Protein/Potential Cytokines.

This gene is a member of the IL-17 receptor family which includes five members (IL-17RA-E) and the encoded protein is a proinflammatory cytokine produced by activated T cells. IL-17A-mediated downstream pathways induce the production of inflammatory molecules, chemokines, antimicrobial peptides, and remodeling proteins. The encoded protein elicits crucial impacts on host defense, cell trafficking, immune modulation, and tissue repair, with a key role in the induction of innate immune defenses. This cytokine stimulates non-hematopoietic cells and promotes chemokine production thereby attracting myeloid cells to inflammatory sites. This cytokine also regulates the activities of NF-kappaB and mitogen-activated protein kinases and can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). IL-17A plays a pivotal role in various infectious diseases, inflammatory and autoimmune disorders, and cancer. High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. The lung damage induced by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is to a large extent, a result of the inflammatory response promoted by cytokines such as IL17A. [provided by RefSeq, Sep 2020]

Target IDGM-T22095
Target NameIL17
Gene ID3605
Gene Official NameIL17A
Gene AliasCTLA-8, CTLA8, IL-17, IL-17A, IL17
Protein Sub-locationSecreted Protein/Potential Cytokines
CategoryTherapeutics Target, INN Index, Cytokine Target, Immuno-oncology Target


Pre-made IL17-specific INN-index biosimilar (antibody&conjugates)-izokibep, Remtolumab, Perakizumab, Netakimab, Ixekizumab, Gumokimab, Bimekizumab, Tibulizumab, Xeligekimab, Secukinumab, Afasevikumab, Vunakizumab, sonelokimab

Anti-IL17 therapeutic INN-index antibodies and conjugates are biosimilars expressed by mammalian cell line as a benchmark reference therapeutic antibody for drug discovery, target MOA research, cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).

Cat No.Products Name (INN Index)INN Name Previous Name Target FormatOrder
GMP-Bios-INN-880Pre-Made Izokibep Biosimilar, Bispecific, Anti-ALB;IL17A/IL17 Antibody: Anti-FDAHT/HSA/PRO0883/PRO0903/PRO1341;CTLA-8/CTLA8A therapeutic antibodyizokibepALB;IL17A/IL17trivalent bispecificINN mab
GMP-Bios-ab-478Pre-Made Remtolumab biosimilar, Bispecific Dual Variable Domain IG: Anti-IL17A/IL17;TNFA/TNF therapeutic antibodyRemtolumabIL17A/IL17;TNFA/TNFBispecific Dual Variable Domain IGINN mab
GMP-Bios-ab-438Pre-Made Perakizumab biosimilar, Whole mAb, Anti-IL17A/IL17 Antibody: Anti-CTLA-8/CTLA8A/ILA17 therapeutic antibodyPerakizumabIL17A/IL17Whole mAbINN mab
GMP-Bios-ab-374Pre-Made Netakimab biosimilar, Whole mAb, Anti-IL17A/IL17 Antibody: Anti-CTLA-8/CTLA8A/ILA17 therapeutic antibodyNetakimabIL17A/IL17Whole mAbINN mab
GMP-Bios-ab-286Pre-Made Ixekizumab biosimilar, Whole mAb, Anti-IL17A/IL17 Antibody: Anti-CTLA-8/CTLA8A/ILA17 therapeutic antibodyIxekizumabIL17A/IL17Whole mAbINN mab
GMP-Bios-ab-671Pre-Made Gumokimab biosimilar, Whole mAb, Anti-IL17A/IL17 Antibody: Anti-CTLA-8/CTLA8A/ILA17 therapeutic antibodyGumokimabIL17A/IL17Whole mAbINN mab
GMP-Bios-ab-070Pre-Made Bimekizumab biosimilar, Whole mAb, Anti-IL17A/IL17 Antibody: Anti-CTLA-8/CTLA8A/ILA17 therapeutic antibodyBimekizumabIL17A/IL17Whole mAbINN mab
GMP-Bios-ab-568Pre-Made Tibulizumab biosimilar, Bispecific Mixed mAb and scFv, Anti-TNFSF13B;IL17A/IL17 Antibody: Anti-BAFF/BLYS/CD257/DTL/TALL-1/TALL1/THANK/TNFSF20/TNLG7A/ZTNF4;CTLA-8/CTLA8A therapeutic antibodyTibulizumabTNFSF13B;IL17A/IL17Bispecific Mixed mAb and scFvINN mab
GMP-Bios-ab-710Pre-Made Xeligekimab biosimilar, Whole mAb, Anti-IL17A/IL17 Antibody: Anti-CTLA-8/CTLA8A/ILA17 therapeutic antibodyXeligekimabIL17A/IL17Whole mAbINN mab
GMP-Bios-ab-510Pre-Made Secukinumab biosimilar, Whole mAb, Anti-IL17A/IL17 Antibody: Anti-CTLA-8/CTLA8A/ILA17 therapeutic antibodySecukinumabIL17A/IL17Whole mAbINN mab
GMP-Bios-ab-012Pre-Made Afasevikumab biosimilar, Whole mAb, Anti-IL17A/IL17 Antibody: Anti-CTLA-8/CTLA8A/ILA17 therapeutic antibodyAfasevikumabIL17A/IL17Whole mAbINN mab
GMP-Bios-ab-633Pre-Made Vunakizumab biosimilar, Whole mAb, Anti-IL17A/IL17 Antibody: Anti-CTLA-8/CTLA8A/ILA17 therapeutic antibodyVunakizumabIL17A/IL17Whole mAbINN mab
GMP-Bios-INN-996Pre-Made Sonelokimab Biosimilar, Bispecific, Anti-ALB;IL17A/IL17;IL17F Antibody: Anti-FDAHT/HSA/PRO0883/PRO0903/PRO1341;CTLA-8/CTLA8/IL-17A/ILA17;CANDF6/ML-1/ML1 therapeutic antibodysonelokimabALB;IL17A/IL17;IL17FBispecificINN mab



Pre-made anti-IL17 inhibitory monoclonal antibody(mab, blocking antibody inhibitor)-benchmark antibody for drug discovery and mechanism of action (MOA) research

Pre-made anti-IL17 benchmark inhibitory monoclonal antibody(mab, blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). The anti-IL17 mab is expressed and produced by mammalian cell line as a benchmark reference therapeutic antibody for biological drug discovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.

Cat No.Antibody NameFormatClassified by tagOrder
GM-Tg-hg-T22095-AbAnti-IL17/IL17A monoclonal antibodymabBiofunctional antibody, Therapeutics Target antibody, Cytokine antibodymonoclonal antibody.




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